Development of a Non–Heart-Beating Donor Program and Results After the First Year. [artículo]
Por: Ávila Martínez, Régulo José [Cirugía Torácica] | Cortés Guerrero, Manuel [Anestesiología y Reanimación] | Martín de Nicolás Serrahima, José Luis [Cirugía Torácica] | Pablo Gafas, Alicia de [Neumología] | Díaz-Hellín Gude, Vicente [Cirugía Torácica] | Gámez García, Pablo [Cirugía Torácica] | Toldos González, Oscar [Anatomía Patológica] | Hermoso Alarza, Fátima [Cirugía Torácica] | Juarros Monteagudo, Lourdes [Medicina Física y Rehabilitación] | Mariscal de Alba, María Andrea [Cirugía Torácica] | Marrón Fernández, María del Carmen [Cirugía Torácica] | Martínez Pueyo, José Ignacio [Cirugía General y Aparato Digestivo] | Meneses Pardo, José Carlos [Cirugía Torácica] | Zuluaga Bedoya, Mauricio [Cirugía Torácica] | López López, Eloisa [Anestesiología y Reanimación].
Colaborador(es): Servicio de Cirugía Torácica | Servicio de Cirugía General y del Aparato Digestivo | Servicio de Anestesiología y Reanimación | Servicio de Neumología | Servicio de Medicina Física y Rehabilitación.
Editor: Transplantation Proceedings, 2012Descripción: 44(7):2047-9.Recursos en línea: Solicitar documento Resumen: Our lung transplant unit began activity in October 2008. We have performed 37 lung transplants with a hospital mortality of 2.7% (n = 1). The need for a greater number of donors and the presence of an already existent non-heart-beating donor (NHBD) program for abdominal grafts and tissues encouraged us to consider assessing lung grafts from these donors. It was necessary to develop a new multiorgan preservation methodology, "bithermia preservation." The clinical experience with which during the first year June 2010 to July 2011, including 15 NHBDs is presented herein. The chest x-ray was normal in 6 donors (40%) and 7 had pulmonary infiltrates. Bronchoscopy was normal in 8 donors (53%) but 3 had abundant bleeding airway secretions and signs of bronchoaspiration. Preservation procedures were performed in 6 donors. Pulmonary functional evaluation in 4 donors showed gas measurements to be adequate in 75% of cases. Three double-lung grafts were judged to be valid for implantation, among which we performed 3 lung transplantations, 1 bilateral and 2 unilaterals, while 2 grafts were offered to the National Transplant Organization for other units. No transplant suffered primary graft dysfunction; all 3 showed excellent function allowing early extubation in 2 cases. There was no in-hospital mortality. All 3 patients are alive and leading normal lives; none has bronchiolitis obliterans syndrome. In conclusion, the "bithermia preservation" methodology achieved adequate lung preservation in NHBDs, allowing liver, kidneys, and lungs to be obtained from the same donor.Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
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Artículo | PC6310 (Navegar estantería) | Disponible |
Formato Vancouver:
Meneses JC, Gámez P, Mariscal A, Marrón C, Díaz-Hellín V, Cortes M, et al. Development of a non-heart-beating donor program and results after the first year. Transplant Proc. 2012 Sep;44(7):2047-9.
PMID: 22974905
Contiene 8 referencias
Our lung transplant unit began activity in October 2008. We have performed 37 lung transplants with a hospital mortality of 2.7% (n = 1). The need for a greater number of donors and the presence of an already existent non-heart-beating donor (NHBD) program for abdominal grafts and tissues encouraged us to consider assessing lung grafts from these donors. It was necessary to develop a new multiorgan preservation methodology, "bithermia preservation." The clinical experience with which during the first year June 2010 to July 2011, including 15 NHBDs is presented herein. The chest x-ray was normal in 6 donors (40%) and 7 had pulmonary infiltrates. Bronchoscopy was normal in 8 donors (53%) but 3 had abundant bleeding airway secretions and signs of bronchoaspiration. Preservation procedures were performed in 6 donors. Pulmonary functional evaluation in 4 donors showed gas measurements to be adequate in 75% of cases. Three double-lung grafts were judged to be valid for implantation, among which we performed 3 lung transplantations, 1 bilateral and 2 unilaterals, while 2 grafts were offered to the National Transplant Organization for other units. No transplant suffered primary graft dysfunction; all 3 showed excellent function allowing early extubation in 2 cases. There was no in-hospital mortality. All 3 patients are alive and leading normal lives; none has bronchiolitis obliterans syndrome. In conclusion, the "bithermia preservation" methodology achieved adequate lung preservation in NHBDs, allowing liver, kidneys, and lungs to be obtained from the same donor.
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