Ávila Martínez, Régulo José Cortés Guerrero, Manuel Martín de Nicolás Serrahima, José Luis Pablo Gafas, Alicia de Díaz-Hellín Gude, Vicente Gámez García, Pablo Toldos González, Oscar Hermoso Alarza, Fátima Juarros Monteagudo, Lourdes Mariscal de Alba, María Andrea Marrón Fernández, María del Carmen Martínez Pueyo, José Ignacio Meneses Pardo, José Carlos Zuluaga Bedoya, Mauricio López López, Eloisa
Development of a Non–Heart-Beating Donor Program and Results After the First Year. [artículo] - Transplantation Proceedings, 2012 - 44(7):2047-9.
Formato Vancouver:
Meneses JC, Gámez P, Mariscal A, Marrón C, Díaz-Hellín V, Cortes M, et al. Development of a non-heart-beating donor program and results after the first year. Transplant Proc. 2012 Sep;44(7):2047-9.
PMID: 22974905
Contiene 8 referencias
Our lung transplant unit began activity in October 2008. We have performed 37 lung transplants with a hospital mortality of 2.7% (n = 1). The need for a greater number of donors and the presence of an already existent non-heart-beating donor (NHBD) program for abdominal grafts and tissues encouraged us to consider assessing lung grafts from these donors. It was necessary to develop a new multiorgan preservation methodology, "bithermia preservation." The clinical experience with which during the first year June 2010 to July 2011, including 15 NHBDs is presented herein. The chest x-ray was normal in 6 donors (40%) and 7 had pulmonary infiltrates. Bronchoscopy was normal in 8 donors (53%) but 3 had abundant bleeding airway secretions and signs of bronchoaspiration. Preservation procedures were performed in 6 donors. Pulmonary functional evaluation in 4 donors showed gas measurements to be adequate in 75% of cases. Three double-lung grafts were judged to be valid for implantation, among which we performed 3 lung transplantations, 1 bilateral and 2 unilaterals, while 2 grafts were offered to the National Transplant Organization for other units. No transplant suffered primary graft dysfunction; all 3 showed excellent function allowing early extubation in 2 cases. There was no in-hospital mortality. All 3 patients are alive and leading normal lives; none has bronchiolitis obliterans syndrome. In conclusion, the "bithermia preservation" methodology achieved adequate lung preservation in NHBDs, allowing liver, kidneys, and lungs to be obtained from the same donor.
Development of a Non–Heart-Beating Donor Program and Results After the First Year. [artículo] - Transplantation Proceedings, 2012 - 44(7):2047-9.
Formato Vancouver:
Meneses JC, Gámez P, Mariscal A, Marrón C, Díaz-Hellín V, Cortes M, et al. Development of a non-heart-beating donor program and results after the first year. Transplant Proc. 2012 Sep;44(7):2047-9.
PMID: 22974905
Contiene 8 referencias
Our lung transplant unit began activity in October 2008. We have performed 37 lung transplants with a hospital mortality of 2.7% (n = 1). The need for a greater number of donors and the presence of an already existent non-heart-beating donor (NHBD) program for abdominal grafts and tissues encouraged us to consider assessing lung grafts from these donors. It was necessary to develop a new multiorgan preservation methodology, "bithermia preservation." The clinical experience with which during the first year June 2010 to July 2011, including 15 NHBDs is presented herein. The chest x-ray was normal in 6 donors (40%) and 7 had pulmonary infiltrates. Bronchoscopy was normal in 8 donors (53%) but 3 had abundant bleeding airway secretions and signs of bronchoaspiration. Preservation procedures were performed in 6 donors. Pulmonary functional evaluation in 4 donors showed gas measurements to be adequate in 75% of cases. Three double-lung grafts were judged to be valid for implantation, among which we performed 3 lung transplantations, 1 bilateral and 2 unilaterals, while 2 grafts were offered to the National Transplant Organization for other units. No transplant suffered primary graft dysfunction; all 3 showed excellent function allowing early extubation in 2 cases. There was no in-hospital mortality. All 3 patients are alive and leading normal lives; none has bronchiolitis obliterans syndrome. In conclusion, the "bithermia preservation" methodology achieved adequate lung preservation in NHBDs, allowing liver, kidneys, and lungs to be obtained from the same donor.
