TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. [artículo]
Por: Pérez Gómez, Eduardo [Instituto de Investigación imas12]
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Colaborador(es): Instituto de Investigación imas12.
Tipo de material: 
ArtículoEditor: Mollecular & cellular oncology, 2015Descripción: 2(3):e980134.Recursos en línea: Acceso libre Resumen: In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
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Artículo
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Formato Vancouver:
Salazar M, Lorente M, García Taboada E, Gómez EP, Dávila D, Zúñiga García P et al. TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Mol Cell Oncol. 2015 Apr 18;2(3):e980134.
PMID: 27308456
PMC4905291
Contiene 10 referencias
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
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