NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis. [artículo]
Por: Benito León, Julián [Neurología]
| Calleja Castaño, Patricia [Neurología] | Díaz Sánchez, María [Neurología].
Colaborador(es): Servicio de Neurología-Neurofisiología.
Tipo de material: 
ArtículoEditor: BMC neurology, 2014Descripción: 14:87.Recursos en línea: Acceso libre Resumen: Background: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.
Methods: We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.
Results: NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.
| Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
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Artículo
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Formato Vancouver:
Agúndez JA, García-Martín E, Martínez C, Benito-León J, Millán-Pascual J, Calleja P et al. NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis. BMC Neurol. 2014 Apr 23;14:87.
PMID: 24755231
PMC4022329
Contiene 49 referencias
Background: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.
Methods: We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.
Results: NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.
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