000			02699na a2200265 4500
003			PC992
005			20220226062802.0
008			130622s2014 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92238 _aAzcárate, Isabel G. _eInstituto de Investigación imas12
100			_91902 _aBautista, José M. _eInstituto de Investigación i+12
100			_aDíez, Amalia _91901 _eInstituto de Investigación i+12
100			_aPuyet, Antonio _91900 _eInstituto de Investigación i+12
245	0	0	_aMalaria proteomics: Insights into the parasite-host interactions in the pathogenic space. _h[artículo]
260			_bJournal of proteomics, _c2014
300			_a97:107-25.
500			_aFormato Vancouver: Bautista JM, Marín-García P, Diez A, Azcárate IG, Puyet A. Malaria proteomics: insights into the parasite-host interactions in the pathogenic space. J Proteomics. 2014 Jan 31;97:107-25.
501			_aPMID: 24140976
504			_aContiene 145 referencias
520			_aProteomics is improving malaria research by providing global information on relevant protein sets from the parasite and the host in connection with its cellular structures and specific functions. In the last decade, reports have described biologically significant elements in the proteome of Plasmodium, which are selectively targeted and quantified, allowing for sensitive and high-throughput comparisons. The identification of molecules by which the parasite and the host react during the malaria infection is crucial to the understanding of the underlying pathogenic mechanisms. Hence, proteomics is playing a major role by defining the elements within the pathogenic space between both organisms that change across the parasite life cycle in association with the host transformation and response. Proteomics has identified post-translational modifications in the parasite and the host that are discussed in terms of functional interactions in malaria parasitism. Furthermore, the contribution of proteomics to the investigation of immunogens for potential vaccine candidates is summarized. The malaria-specific technological advances in proteomics are particularly suited now for identifying host-parasite interactions that could lead to promising targets for therapy, diagnosis or prevention. In this review, we examine the knowledge gained on the biology, pathogenesis, immunity and diagnosis of Plasmodium infection from recent proteomic studies. This article is part of a Special Issue entitled: Trends in Microbial Proteomics.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/9/pc992.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c992 _d992