000 02216na a2200253 4500
003 PC9733
005 20210625062810.0
008 130622s2011 xxx||||| |||| 00| 0 eng d
040 _cH12O
041 _aeng
100 _91016
_aDelgado Vázquez, Rafael
_eMicrobiología y Parasitología
100 _aLuczkowiak, Joanna
_91611
_eMicrobiología y Parasitología
245 0 0 _aPseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection
_h[artículo]
260 _bBioconjugate Chemistry,
_c2011.
300 _a22(7):1354-1365.
500 _aFormato Vancouver: Luczkowiak J, Sattin S, Sutkevičiūtė I, Reina JJ, Sánchez-Navarro M, Thépaut M, et al. Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection. Bioconjug Chem. 2011;22(7):1354-65.
501 _aPMID:21650462
504 _aContiene 44 referencias.
520 _aThe development of compounds with strong affinity for the receptor DC-SIGN is a topic of remarkable interest due to the role that this lectin plays in several pathogen infection processes and in the modulation of the immune response. DC-SIGN recognizes mannosylated and fucosylated oligosaccharides in a multivalent manner. Therefore, multivalent carbohydrate systems are required to interact in an efficient manner with this receptor and compete with the natural ligands. We have previously demonstrated that linear pseudodi- and pseudotrisaccharides are adequate ligands for DC-SIGN. In this work, we show that multivalent presentations of these glycomimetics based on polyester dendrons and dendrimers lead to very potent inhibitors (in the nanomolar range) of cell infection by Ebola pseudotyped viral particles by blocking DC-SIGN receptor. Furthermore, SPR model experiments confirm that the described multivalent glycomimetic compounds compete in a very efficient manner with polymannosylated ligands for binding to DC-SIGN.
710 _981
_aServicio de Microbiología y Parasitología
710 _9625
_aInstituto de Investigación imas12
856 _uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/9/pc9733.pdf
_ySolicitar documento
942 _2ddc
_cART
_n0
999 _c9733
_d9733