000			02329na a2200229 4500
003			H12O
005			20180417112801.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aPérez-Regadera Gómez, José Fermín _91799 _eOncología Radioterápica
245	0	0	_aEarly-stage breast cancer conservative treatment: high-dose-rate brachytherapy boost in a single fraction of 700 cGy to the tumour bed. _h[artículo]
260			_bClinical and Translational Oncology, _c2012
300			_a14(5):362-8.
500			_aFormato Vancouver: Rodríguez Pérez A, Samper Ots PM, López Carrizosa MC, Pérez-Regadera Gómez JF, Zapatero Ortuño J, Sáez Garrido Jde D, et al. Early-stage breast cancer conservative treatment: high-dose-rate brachytherapy boost in a single fraction of 700 cGy to the tumour bed. Clin Transl Oncol. 2012 May;14(5):362-8.
501			_aPMID: 22551542
504			_aContiene 36 referencias
520			_aBACKGROUND AND PURPOSE: Conservative treatment represents the current therapy for early-stage breast cancer. When risk factors for local relapse exist, a tumour bed boost is required. Retrospectively, we evaluated the prognostic factors influencing local recurrence (LR), overall survival (OS) and disease-free survival (DFS). MATERIAL AND METHODS: After conservative treatment, 210 patients received a single-dose HDR brachytherapy (HDRBT) boost between June 1996 and December 2005. Mean age was 57 years; 75% had invasive ductal carcinoma. The most frequent surgery was lumpectomy (55.7%); 39.4% were G3, 18.6% intraductal component >25% and only 22% had negative margins. RESULTS: With a mean follow-up of 85 months, at 5 and 10 years the OS was 93% and 88%, DFS 92% and 89%, and LR 3.6% and 5.3%, respectively. For LR, the risk factors were carcinoma in situ, N+ and involved margins, whereas for metastasis, the risk factors were T2 tumours, stage III, N+ and the presence of local recurrence. CONCLUSIONS: HDR-BT boost in one fraction is an effective, simple and safe method for reducing LR. The outpatient setting and shorter treatment duration represent undeniable advantages.
710			_9302 _aServicio de Oncología Radioterápica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/9/pc9657.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c9657 _d9657