000			03929na a2200553 4500
999			_c9440 _d9440
003			PC9440
005			20210625062809.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aGarcía Ruiz, Inmaculada _91460 _eInstituto de Investigación i+12
100			_aMuñoz Yagüe, María Teresa _91461 _eAparato Digestivo
100			_aSolís Herruzo, José Antonio _9514 _eAparato Digestivo
245	0	0	_aPioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain. _h[artículo]
260			_bBMC biology, _c2013
300			_a11:88.
500			_aFormato Vancouver: García-Ruiz I, Solís-Muñoz P, Fernández-Moreira D, Muñoz-Yagüe T, Solís-Herruzo JA. Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain. BMC Biol. 2013 Aug 1;11:88.
501			_aPMID: 23915000
504			_aContiene 43 referencias
520			_aBACKGROUND: Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mechanisms of the latter effects are unclear. The aim of this study was to determine the mechanisms by which pioglitazone (PGZ), a member of the thiazolidinedione class of antidiabetic agents, decreases the activity of the MRC. In isolated mitochondria from mouse liver, we measured the effects of PGZ treatment on MRC complex activities, fully-assembled complex I and its subunits, gene expression of complex I and III subunits, and [3H]PGZ binding to mitochondrial complexes.
710			_9273 _aServicio de Medicina del Aparato Digestivo
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751493/ _yAcceso libre
942			_n0 _2ddc _cART