000			02759na a2200229 4500
003			PC9087
005			20210625062809.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91013 _aMorán Jiménez, María Josefa _eInstituto de Investigación i+12
245	0	0	_aAre centenarians genetically predisposed to lower disease risk?. _h[artículo]
260			_bAge (Dordrecht, Netherlands), _c2012
300			_a34(5):1269-83.
500			_aFormato Vancouver: Ruiz JR, Fiuza-Luces C, Buxens A, Cano-Nieto A, Gómez-Gallego F, Santiago C, et al. Are centenarians genetically predisposed to lower disease risk? Age (Dordr). 2012 Oct;34(5):1269-83.
501			_aPMID: 21894447
504			_aContiene 94 referencias
520			_aOur study purpose was to compare a disease-related polygenic profile that combined a total of 62 genetic variants among (i) people reaching exceptional longevity, i.e., centenarians (n = 54, 100-108 years, 48 women) and (ii) ethnically matched healthy controls (n = 87, 19-43 years, 47 women). We computed a 'global' genotype score (GS) for 62 genetic variants (mutations/polymorphisms) related to cardiometabolic diseases, cancer or exceptional longevity, and also specific GS for main disease categories (cardiometabolic risk and cancer risk, including 36 and 24 genetic variations, respectively) and for exceptional longevity (7 genetic variants). The 'global' GS was similar among groups (centenarians: 31.0 ± 0.6; controls 32.0 ± 0.5, P = 0.263). We observed that the GS for hypertension, cancer (global risk), and other types of cancer was lower in the centenarians group compared with the control group (all P < 0.05), yet the difference became non significant after adjusting for sex. We observed significant between-group differences in the frequency of GSTT1 and GSTM1 (presence/absence) genotypes after adjusting for multiple comparisons. The likelihood of having the GSTT1 low-risk (functional) allele was higher in centenarians (odds ratio [OR] 5.005; 95% confidence interval [CI], 1.810-13.839), whereas the likelihood of having the GSTMI low-risk (functional) allele was similar in both groups (OR 1.295; 95% CI, 0.868 -1.931). In conclusion, we found preliminary evidence that Spanish centenarians have a lower genetic predisposition for cancer risk. The wild-type (i.e., functional) genotype of GSTT1, which is associated with lower cancer risk, might be associated with exceptional longevity, yet further studies with larger sample sizes must confirm these findings.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448993/pdf/11357_2011_Article_9296.pdf _yAcceso libre
942			_n0 _2ddc _cART
999			_c9087 _d9087