000			03078na a2200385 4500
003			H12O
005			20210625062755.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9876 _aAguado García, José María _eEnfermedades Infecciosas
100			_aAndrés Belmonte, Amado _91321 _eNefrología
100			_9263 _aFernández Ruiz, Mario _eMedicina Interna
100			_91210 _aGarcía Reyne, Ana _eMedicina Interna
100			_aGonzález Monte, Esther _91487 _eNefrología
100			_9162 _aLópez Medrano, Francisco _eEnfermedades Infecciosas
100			_9821 _aLora Pablos, David _eInstituto Investigación I+12
100			_aLumbreras Bermejo, Carlos _9873 _eMedicina Interna
100			_9576 _aMorales Cerdán, José María _eNefrología
100			_aPaz Artal, Estela _91510 _eInmunología
100			_aSan Juan Garrido, Rafael _9869 _eMedicina Interna
245	0	0	_aMonitoring of immunoglobulin levels identifies kidney transplant recipients at high risk of infection _h[artículo]
260			_bAmerican Journal of Transplantation, _c2012
300			_a12(10):2763-2773.
500			_aFormato Vancouver: Fernández-Ruiz M, López-Medrano F, Varela-Peña P, Lora-Pablos D, García-Reyne A, González E, et al. Monitoring of immunoglobulin levels identifies kidney transplant recipients at high risk of infection. Am J Transplant. 2012;12(10):2763-73.
501			_aPMID: 22823002
504			_aContiene 37 referencias
520			_aWe aimed to analyze the incidence, risk factors and impact of hypogammaglobulinemia (HGG) in 226 kidney transplant (KT) recipients in which serum immunoglobulin (Ig) levels were prospectively assessed at baseline, month 1 (T(1) ), and month 6 (T(6) ). The prevalence of IgG HGG increased from 6.6% (baseline) to 52.0% (T(1) ) and subsequently decreased to 31.4% (T(6) ) (p < 0.001). The presence of IgG HGG at baseline (odds ratio [OR] 26.9; p = 0.012) and a positive anti-HCV status (OR 0.17; p = 0.023) emerged as risk factors for the occurrence of posttransplant IgG HGG. Patients with HGG of any class at T(1) had higher incidences of overall (p = 0.018) and bacterial infection (p = 0.004), bacteremia (p = 0.054) and acute pyelonephritis (p = 0.003) in the intermediate period (months 1-6). Patients with HGG at T(6) had higher incidences of overall (p = 0.004) and bacterial infection (p < 0.001) in the late period (>6 month). A complementary log-log model identified posttransplant HGG as an independent risk factor for overall (hazard ratio [HR] 2.03; p < 0.001) and bacterial infection (HR 2.68; p < 0.0001). Monitoring of humoral immunity identifies KT recipients at high risk of infection, offering the opportunity for preemptive immunoglobulin replacement therapy.
710			_96 _aServicio de Medicina Interna
710			_9395 _aServicio de Inmunología
710			_986 _aServicio de Nefrología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc880.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c880 _d880