000			02905na a2200421 4500
999			_c8624 _d8624
003			PC8624
005			20210706062655.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aDelgado Jiménez, Juan Francisco _91250 _eCardiología
245	0	0	_aPrimary graft failure after heart transplantation: Characteristics in a contemporary cohort and performance of the RADIAL risk score. _h[artículo]
260			_bJournal of Heart and Lung Transplantation, _c2013
300			_a32(12):1187-95.
500			_aFormato Vancouver: Cosío Carmena MD, Gómez Bueno M, Almenar L, Delgado JF, Arizón JM, González Vilchez F et al. Primary graft failure after heart transplantation: characteristics in a contemporary cohort and performance of the RADIAL risk score. J Heart Lung Transplant. 2013 Dec;32(12):1187-95.
501			_aPMID: 24263021
504			_aContiene 20 referencias
520			_aBACKGROUND: Primary graft failure (PGF) is the leading cause of early heart transplantation (HT) mortality. Our aim was to analyze PGF currently and explore the ability of a dedicated score for PGF risk stratification. METHODS: After applying a dedicated PGF definition, we analyzed its incidence, mortality, and associated factors in a multicenter cohort of 857 HTs performed in 2006 to 2009. We used the following criteria: recipient right (R) atrial pressure >= 10 mm Hg; age (A) >= 60 years; diabetes (D) mellitus, and inotrope (I) dependence; donor age (A) >= 30 years, and length (L) of ischemia >= 240 minutes to calculate the RADIAL score for PGF risk prediction. RESULTS: PGF incidence was 22%. The right ventricle was almost always affected, alone (45%) or as part of biventricular failure (47%). Mechanical circulatory support was used in 55%. Mortality attributable to PGF was 53% and extended through the third month after HT, but thereafter, PGF had little influence in long-term outcome. The RADIAL score was higher in PGF patients (2.78 +/- 1.1 vs 2.42 +/- 1.1, p = 0.001) and stratified 3 groups with incremental PGF incidence: low risk (12.1%), intermediate risk (19.4%), and high risk (27.5%, p = 0.001). CONCLUSIONS: PGF had a strong impact, with an incidence of 22% and a mortality exceeding 50% that extends through the third post-HT month. The RADIAL score classified patients into 3 groups with incremental risk for PGF and may be useful for its prevention and early therapy.
710			_9119 _aServicio de Cardiología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc8624.pdf _ySolicitar documento
942			_n0 _2ddc _cART