000			02348na a2200241 4500
003			8613
005			20210625062808.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aLeza, Juan Carlos _91995 _eInstituto de Investigación i+12
100			_91994 _aMac-Dowell, Karina Soledad _eInstituto de Investigación i+12
245	0	0	_aPlasma antioxidant capacity is reduced in Asperger syndrome _h[artículo]
260			_bJournal of Psychiatric Research, _c2012
300			_a46(3):394-401.
500			_aFormato Vancouver: Parellada M, Moreno C, Mac-Dowell K, Leza JC, Giráldez M, Bailón C, et al. Plasma antioxidant capacity is reduced in Asperger syndrome. J Psychiatr Res. 2012;46(3):394-401.
501			_aPMID: 22225920
504			_aContiene 81 referencias
520			_aRecent evidence suggests that children with autism have impaired detoxification capacity and may suffer from chronic oxidative stress. To our knowledge, there has been no study focusing on oxidative metabolism specifically in Asperger syndrome (a milder form of autism) or comparing this metabolism with other psychiatric disorders. In this study, total antioxidant status (TAOS), non-enzymatic (glutathione and homocysteine) and enzymatic (catalase, superoxide dismutase, and glutathione peroxidase) antioxidants, and lipid peroxidation were measured in plasma or erythrocyte lysates in a group of adolescent patients with Asperger syndrome, a group of adolescents with a first episode of psychosis, and a group of healthy controls at baseline and at 8-12 weeks. TAOS was also analyzed at 1 year. TAOS was reduced in Asperger individuals compared with healthy controls and psychosis patients, after covarying by age and antipsychotic treatment. This reduced antioxidant capacity did not depend on any of the individual antioxidant variables measured. Psychosis patients had increased homocysteine levels in plasma and decreased copper and ceruloplasmin at baseline. In conclusion, Asperger patients seem to have chronic low detoxifying capacity. No impaired detoxifying capacity was found in the first-episode psychosis group in the first year of illness.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc8613.pdf _ySolicitar documento
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999			_c8613 _d8613