000			02880na a2200301 4500
003			H12O
005			20210625062807.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBenito León, Julián _9892 _eNeurología
100			_9582 _aBermejo Pareja, Félix _eNeurología
100			_aPosada Rodríguez, Ignacio Javier _91766 _e Neurología _e
100			_aSánchez Ferro, Álvaro _91767 _eNeurología
100			_9715 _aTrincado Soriano, Rocío _eInstituto de Investigación i+12
100			_9423 _aVillarejo Galende, Alberto _eNeurología
245	0	0	_aPremotor cognitive status in a cohort of incident Parkinson disease patients (NEDICES) _h[artículo]
260			_bJournal of the Neurological Sciences, _c2011
300			_a310(1-2):211-215.
500			_aFormato Vancouver: Sánchez Ferro Á, Benito León J, Mitchell AJ, Louis ED, Posada IJ, Trincado R, et al. Premotor cognitive status in a cohort of incident Parkinson disease patients (NEDICES). J Neurol Sci. 2011;310(1-2):211-5.
501			_aPMID: 21621225
504			_aContiene 43 referencias
520			_aA variety of symptoms may precede the classical motor features of Parkinson disease (PD). However, it is not known whether cognitive dysfunction precedes the motor phase of PD. We examined whether patients with incident PD had had global cognitive function disturbances three years prior to diagnosis when compared with matched controls in a cohort of community-dwelling subjects. Methods: All participants were age 65 years or older (median 76 years) and were enrolled in the Neurological Disorders in Central Spain (NEDICES) study in central Spain. We identified all participants with incident PD (N=23), diagnosed in the follow-up examination (1997-1998), who had performed an expanded 37-item version of the Mini-Mental State Examination (37-MMSE) at the baseline evaluation (1994-1995). These 23 were 1:4 matched to 92 controls. Results: Baseline 37-MMSE scores were 27.9 +/- 4.9 (28) in PD patients and 28.7 +/- 6.5 (31) in controls (p=0.212). There were no patient-control differences in orientation, immediate recall, attention and calculation, memory recall, language, or visuospatial copying. In analyses that adjusted for several possible confounding factors, there were no case-control differences. Conclusions: In this population-based sample, patients with incident PD did not have evidence of significant global cognitive function disturbances three years prior to their diagnosis when compared with matched controls. Our data suggest that global cognitive dysfunction does not precede the diagnosis of PD.
710			_9267 _aServicio de Neurología-Neurofisiología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc8240.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c8240 _d8240