000			02774na a2200229 4500
003			H12O
005			20180417112632.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9441 _aUrruzuno Tellería, Pedro _ePediatría
245	0	0	_aNew Effective Treatment Regimen for Children Infected With a Double-resistant Helicobacter pylori Strain _h[artículo]
260			_bJournal of Pediatric Gastroenterology and Nutrition, _c2011
300			_a52(4):424-428.
500			_aFormato Vancouver: Schwarzer A, Urruzuno P, Iwańczak B, Martínez-Gómez MZ, Kalach N, Roma-Giannikou E, et al. New effective treatment regimen for children infected with a double-resistant Helicobacter pylori strain. J Pediatr Gastroenterol Nutr. 2011;52(4):424-8.
501			_aPMID: 21407111
504			_aContiene 36 referencias
520			_aBackground: The increasing number of pediatric patients infected with multiresistant Helicobacter pylori strains calls for evaluation of treatment regimens. Second-line antibiotics such as tetracycline or quinolones are not licensed for children. Because in vivo resistance to metronidazole may be overcome in vivo by a high dose and prolonged intake, we evaluated the eradication rate and side effects of a high-dose triple therapy in pediatric patients with culture-proven double resistance. Patients and Methods: In this open multicentre trial, 62 children (<18 years, body weight >15 kg) infected with an H pylori strain resistant to metronidazole and clarithromycin were treated according to body weight classes with amoxicillin (similar to 75 mg/kg/day), metronidazole (similar to 25 mg/kg/day) and esomeprazole (similar to 1.5 mg/kg/day) for 2 weeks. Adherence and adverse events were assessed by a 2-week diary and telephone interviews at days 7 and 14 of treatment. Primary outcome was a negative (13)C-urea breath test after 6 weeks. Results: Of 62 patients, 5 were lost to follow-up, 12 were nonadherent, and 45 treated per protocol. Eradication rates were 66% (41/62) [confidence interval 54-78] (intention to treat) and 73% (33/45) [confidence interval 60-86] (per protocol). Success of treatment was not related to dose per kilogram body weight. Mild to moderate adverse events were reported by 21 patients, including nausea (10.8%), diarrhoea (8.9%), vomiting (7.1%), abdominal pain (5.4%), and headache (3.6%), and led to discontinuation in 1 child. Conclusion: High-dose amoxicillin, metronidazole, and esomeprazole for 2 weeks is a good treatment option in children infected with a double resistant H pylori strain.
710			_9446 _aServicio de Pediatría-Neonatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc8084.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c8084 _d8084