000			02139na a2200265 4500
003			H12O
005			20180417112632.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aCastañeda Altamirano, Carlos _91790 _eOncología Médica
100			_aCiruelos Gil, Eva María _91082 _eOncología Médica
100			_aCortés-Funes Castro, Hernán _91181 _eOncología Médica
100			_aAgulló Ortuño, María Teresa _91791 _eOncología Médica
245	0	0	_aImplication of miRNA in the diagnosis and treatment of breast cancer _h[artículo]
260			_bExpert Review of Anticancer Therapy, _c2011
300			_a11(8):1265-1275.
500			_aFormato Vancouver: Castañeda CA, Agullo-Ortuño MT, Fresno Vara JA, Cortes-Funes H, Gomez HL, Ciruelos E. Implication of miRNA in the diagnosis and treatment of breast cancer. Expert Rev Anticancer Ther. 2011 Aug;11(8):1265-75.
501			_aPMID: 21916580
504			_aContiene 112 referencias
520			_aBreast cancer (BC) comprises a group of different diseases characterized by changes in tissue structure and gene expression. Recent advances in molecular biology have shed new light on the participation of genes and their products in the biology of BC. MicroRNAs (miRNAs) are small noncoding endogenous RNA molecules that appear to modulate the expression of more than a third of human genes, and their implications in cancer have grasped the attention of the scientific community. Recently, several studies have described the association between miRNA expression profiles and pathological and clinical BC features. Moreover, these molecules represent a new type of molecular marker that can identify prognosis and guide the management of BC patients. With the increasing understanding of miRNA networks and their impact in the biology of BC, as well as the development of viable strategies to modulate specific miRNAs, we could improve the treatment of this disease.
710			_9303 _aServicio de Oncología Médica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc8000.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c8000 _d8000