000			02677na a2200433 4500
999			_c7706 _d7706
003			PC7706
005			20210625062807.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBautista, José M. _91902 _eInstituto de Investigación i+12
245	0	0	_aFunctional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). _h[artículo]
260			_bFaseb Journal, _c2013
300			_a27(2):424-31.
500			_aFormato Vancouver: Rodríguez de la Vega Otazo M, Lorenzo J, Tort O, Avilés FX, Bautista JM. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). FASEB J. 2013 Feb;27(2):424-31.
501			_aPMID: 23085998
504			_aContiene 50 referencias
520			_aRecent experimental data indicating axonal regeneration, axogenesis, dendritogenesis, and ciliary axoneme assembly and wellness have linked the role of cytosolic metallocarboxypeptidase 1 (CCP1/AGTPBP1/Nna1) to the microtubule network. In addition, 5 of the 6 mammalian ccp genes have been shown to participate in post-translational modifications of tubulin, which occur in the microtubules of neurons, mitotic spindles, cilia, and basal bodies. Here, we compile evidence for the idea that the occurrence of CCPs strongly correlates with the presence of cilia, suggesting that CCP functions might be primarily related to cilia and basal bodies (CBBs). In agreement with this hypothesis, CCPs were localized in centrioles, basal bodies, and mitotic spindles in HeLa cells by confocal microscopy. By reconstructing the evolutionary history of CCPs, we show their presence in the last eukaryotic common ancestor and relate each group of CCP orthologs to specific roles in CBBs. The clues presented in this study suggest that during the evolution of eukaryotes, mechanisms mediated by CCPs through tubulin post-translational modifications controlling assembly, trafficking, and signaling in the microtubules, were transferred from cilia to cell and axon microtubules.-Rodriguez de la Vega Otazo, M., Lorenzo, J., Tort, O., Aviles, F. X., Bautista, J. M. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/7/pc7706.pdf _ySolicitar documento
942			_n0 _2ddc _cART