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_c728 _d728 |
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003 | PC728 | ||
005 | 20210625062754.0 | ||
008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
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041 | _aeng | ||
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_aGarcía Bueno, Borja _91897 _eInstituto de Investigación i+12 |
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_aLeza, Juan Carlos _91995 _eInstituto de Investigación i+12 |
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_aMacDowell, Karina S. _92610 _eInstituto de Investigación i+12 |
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_92441 _aMuñoz Madrigal, José Luis _eInstituto de Investigación i+12 |
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_aParellada, Mara _92611 _eInstituto de Investigación i+12 |
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_aRisperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation. _h[artículo] |
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_c2013 _bInternational Journal of Neuropsychopharmacology, |
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300 | _a16(1):121-35. | ||
500 | _aFormato Vancouver: MacDowell KS, García-Bueno B, Madrigal JL, Parellada M, Arango C, Micó JA, et al. Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation. Int J Neuropsychopharmacol. 2013 Feb;16(1):121-35. | ||
501 | _aPMID: 22176740 | ||
504 | _aContiene 68 referencias | ||
520 | _aInflammation, caused by both external and endogenous factors, has been implicated as a main pathophysiological feature of chronic mental illnesses, including schizophrenia. An increase in pro-inflammatory cytokines has been described both in experimental models and in schizophrenia patients. However, not much is known about the effects that antipsychotic drugs have on intra-and intercellular mechanisms controlling inflammation. The aim of the present study was to investigate the possible anti-inflammatory effect of a standard schizophrenia treatment not only at the level of soluble mediators, but also at intra-and intercellular inflammatory pathways. The present study was conducted in a model of mild neuroinflammation using a lipopolysaccharide (LPS) challenge that was not an endotoxaemic dose (0.5 mg/kg i.p.) in young adult rats. Main results : single doses of risperidone (0.3-3.0 mg/kg i.p.) prevented increased inflammatory parameters induced by LPS in brain cortex [expression of inflammatory cytokines, interleukin (IL)-1 beta and tumour necrosis factor (TNF)-alpha, activity of the inducible inflammatory enzymes nitric oxide synthase and cyclooxygenase, p38 mitogen-activated protein kinase (MAPK) and inflammatory nuclear transcription factor kappa B] and restored anti-inflammatory pathways decreased by LPS challenge (deoxyprostaglandins and peroxisome proliferator activated receptor c). This is the first study demonstrating that risperidone elicits a preventive effect on the anti-inflammatory arm of the homeostatic mechanism controlling inflammation in a model of mild encephalitis in rats. Our findings suggest a possible protective effect of risperidone on brain cells. | ||
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_9625 _aInstituto de Investigación imas12 |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/7/pc728.pdf _ySolicitar documento |
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