000			02341na a2200409 4500
999			_c6881 _d6881
003			PC6881
005			20210423142554.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9652 _aFranco Ugidos, Alejandro _eAparato Digestivo
245	0	0	_aSecond-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection Time Trends in a Spanish Multicenter Study of 1000 Patients. _h[artículo]
260			_bJournal of clinical gastroenterology, _c2013
300			_a47(2):130-5.
500			_aFormato Vancouver: Gisbert JP, Pérez-Aisa A, Bermejo F, Castro-Fernández M, Almela P, Barrio J et al. H. pylori Study Group of the Asociación Española de Gastroenterología (Spanish Gastroenterology Association). Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. J Clin Gastroenterol. 2013 Feb;47(2):130-5.
501			_aPMID: 22647827
504			_aContiene 47 referencias
520			_aBackground: Second-line bismuth-containing quadruple therapy is complex and frequently induces adverse effects. A triple rescue regimen containing levofloxacin is a potential alternative; however, resistance to quinolones is rapidly increasing. Aim: To evaluate the efficacy and tolerability of a second-line triple-regimen-containing levofloxacin in patients whose Helicobacter pylori eradication treatment failed and to assess whether the efficacy of the regimen decreases with time. Methods: Design: Prospective multicenter study. Patients: In whom treatment with a regimen comprising a proton-pump inhibitor, clarithromycin, and amoxicillin had failed. Intervention: Levofloxacin (500mg bid), amoxicillin (1 g bid), and omeprazole (20mg bid) for 10 days. Outcome: Eradication was confirmed using the C-13-urea breath test 4 to 8 weeks after therapy. Compliance/tolerance: Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by means of a questionnaire.
710			_9273 _aServicio de Medicina del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/6/pc6881.pdf _ySolicitar documento
942			_n0 _2ddc _cART