000			nam a22 4500
999			_c667 _d667
003			PC667
005			20210625062754.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aMonsálvez Honrubia, Verónica _92456 _eInstituto de Investigación i+12
100			_aOrtiz Romero, Pablo Luis _91223 _eDermatología Médico-Quirúrgica y Venereología
100			_aRodríguez Peralto, José Luis _91219 _eAnatomía Patológica
245	0	0	_aMicroRNAs as prognostic markers in indolent primary cutaneous B-cell lymphoma, _h[artículo]
260			_bModern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc, _c2013
300			_a26(4):617.
500			_aFormato Vancouver: Monsálvez V, Montes-Moreno S, Artiga MJ, Rodríguez ME, Espiridión BS, Lozano M et al. MicroRNAs as prognostic markers in indolent primary cutaneous B-cell lymphoma. Mod Pathol. 2013 Apr;26(4):617.
501			_aPMID:23542528
504			_aContiene 52 referencias
520			_aIndolent primary cutaneous B-cell lymphoma is a group of malignant lymphomas comprising marginal zone B-cell lymphoma and centrofollicular B-cell lymphoma. Relapse rate of these tumors is close to 40%, and identifying those patients who are likely to progress remains a challenge. The aim of this study was to characterize the microRNA (miRNA) expression profile of a series of primary cutaneous B-cell lymphomas and correlate with histological and clinical findings. We studied a series of 68 patients with primary cutaneous B-cell lymphomas (30 cutaneous marginal-zone B-cell lymphomas and 38 primary cutaneous centrofollicular lymphomas). A set of 11 miRNAs associated with the differentiation stage of B cells was quantified by real-time PCR, using RNA extracted from formalin-fixed, paraffin-embedded tissue diagnostic samples. Relevant clinical variables were retrieved in a subset of 57 patients (28 cutaneous marginal zone B-cell lymphomas and 29 primary cutaneous centrofollicular lymphomas). miR-150 was upregulated in cutaneous marginal zone B-cell lymphomas relative to primary cutaneous centrofollicular lymphoma samples (false discovery rate <0.05). miR-155 and miR-150 expression levels were associated with progression-free survival in a univariate Cox regression analysis (P<0.1). After stratification by histological subtype, low-expression levels of miR-155 and miR-150 were both associated with shorter progression-free survival only in primary cutaneous marginal zone B-cell lymphomas cases (log-rank test, P<0.05). In summary, miRNA expression analysis can be used as a tool for diagnosis and outcome prognosis in indolent primary cutaneous B-cell lymphoma.
710			_9330 _aServicio de Anatomía Patológica
710			_9145 _aServicio de Dermatología Médico-Quirúrgica y Venereología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/6/pc667.pdf _ySolicitar documento
942			_n0 _2ddc _cART