000			03030na a2200337 4500
003			H12O
005			20210625062754.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9876 _aAguado García, José María _eEnfermedades Infecciosas
100			_978 _aChaves Sánchez, Fernando _eMicrobiología y Parasitología
100			_9263 _aFernández Ruiz, Mario _eMedicina Interna
100			_9162 _aLópez Medrano, Francisco _eEnfermedades Infecciosas
100			_9206 _aOrigüen Sabater, Julia _eEnfermedades Infecciosas
100			_aPanizo Mota, Fernando _92011 _eEnfermedades Infecciosas
100			_aSan Juan Garrido, Rafael _9869 _eMedicina Interna
100			_91506 _aSanz Sanz, Francisca _eMicrobiología y Parasitología
245	0	0	_aClinical significance of Candida colonization of intravascular catheters in the absence of documented candidemia _h[artículo]
260			_bDiagnostic Microbiology and Infectious Disease, _c2012
300			_a73(2):157-161.
500			_aFormato Vancouver: López-Medrano F, Fernández-Ruiz M, Origüen J, Belarte-Tornero LC, Carazo-Medina R, Panizo-Mota F, et al. Clinical significance of Candida colonization of intravascular catheters in the absence of documented candidemia. Diagn Microbiol Infect Dis. 2012;73(2):157-61.
501			_aPMID: 22483190
504			_aContiene 17 referencias
520			_aIn order to assess the significance of Candida colonization of intravascular catheters (IVC) in patients without documented candidemia, we retrospectively reviewed all Candida-positive IVC tip cultures over a 4-year period. Cases were defined as those with a culture yielding ≥15 colony-forming units of Candida spp. that either did not have blood cultures (BC) taken or had concomitant BC negative for Candida. Patients were followed up until death or 8 months after discharge. Risk factors for poor outcome following IVC removal (death, candidemia, or Candida-related complication) were analyzed. We analyzed a total of 40 patients. Overall mortality was 40.0%, with no death directly attributed to Candida infection. Twenty-two patients received antifungal therapy at the time of IVC removal. Only 1 patient developed a metastatic complication (chorioretinitis) attributable to transient candidemia (2.5% of the global cohort and 3.7% among those with concomitant BC). There were no cases of subsequent candidemia. In the multivariate analysis, the use of antifungal therapy did not show any impact on the risk of poor outcome. The risk of invasive disease in patients with isolated IVC colonization by Candida seems to be low. Nevertheless, the initiation of systemic antifungal therapy should be carefully considered in such context.
710			_96 _aServicio de Medicina Interna
710			_981 _aServicio de Microbiología y Parasitología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/6/pc658.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c658 _d658