000			01551na a2200337 4500
999			_c6244 _d6244
003			PC6244
005			20190820135010.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aGonzález Tomé, María Isabel _91354 _ePediatría
245	0	4	_aThe CD4/CD8 Ratio as a Marker T-cell Activation, Senescence and Activation/Exhaustion in Treated HIV-Infected Children and Young Adults _h[artículo]
260			_bAIDS (London, England), _c2013
300			_a27(9):1513-6.
500			_aFormato Vancouver: Sainz T, Serrano-Villar S, Díaz L, González Tomé MI, Gurbindo MD, de José MI et al. The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults. AIDS. 2013 Jun 1;27(9):1513-6.
501			_aPMID: 23435292
504			_aContiene 21 referencias
520			_aWe explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4and CD8 T-cells, and a skewed T-cell phenotype from naïve toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify subjects with higher immunoactivation despite ART.
710			_9446 _aServicio de Pediatría-Neonatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/6/pc6244.pdf _ySolicitar documento
942			_n0 _2ddc _cART