000			02277na a2200241 4500
003			PC5961
005			20180417114634.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9624 _aHernández Laín, Aurelio _e Anatomía Patológica
245	0	0	_aFunctional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion _h[artículo]
260			_bNeuroscience Research, _c2011.
300			_a69(2):144-153.
337			_a
500			_aFormato Vancouver: Hernández-Laín A, Piedras MJ, Cavada C. Functional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion. Neurosci Res. 2011Feb;69(2):144-53.
501			_aPMID: 21093503
504			_aContiene 29 referencias.
520			_aWe report on the neurological and neurophysiological findings obtained from two adult Macaca mulatta sustaining complete spinal cord transections at T8-T9. We performed periodic neurological exams, recorded motor evoked potentials (MEPs) following transcranial magnetic stimulation (TMS), and recorded electromyograms (EMGs) during the execution of a lower limb motor test. The main observations were: (1) the spinal shock period lasted less than a week; tendon, cutaneous and withdrawal reflexes were uneven in range and occurrence, and Babinski's sign was not observed; (2) a protracted functional lesion in the tibial and common peroneal nerves appeared bilaterally early in the post-lesional period; (3) MEPs were elicited by TMS in the quadriceps muscle of both monkeys; they were recorded as early as the 5th week after lesion in one of the monkeys, and they persisted throughout the post-lesional period in both monkeys; and (4) motor unit action potentials in the quadriceps muscle recorded by EMG were simultaneous with attempts to perform intentional lower limb movements from post-lesion month 11 to 13.5 in both monkeys. The last two sets of observations argue in favor of a partial cortico-spinal functional gain and suggest that spinal cord regeneration can occur after complete spinal cord injury in primates.
710			_9330 _aServicio de Anatomía Patológica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc5961.pdf _ySolicitar documento
942			_2ddc _cART _n0
999			_c5961 _d5961