000			02529na a2200253 4500
003			H12O
005			20180417112610.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91798 _aLanzos González, Eduardo _eOncología Radioterápica
100			_aPeña Sánchez, Carmen _91799 _eOncología Radioterápica
245	0	0	_aMicrobiological effects of an antiseptic mouthrinse in irradiated cancer patients _h[artículo]
260			_bMedicina Oral Patología Oral y Cirugia Bucal, _c2011
300			_a16(7):e1036-e1042.
500			_aFormato Vancouver: Lanzós I, Herrera D, Santos S, O'Connor A, Peña C, Lanzós E, Sanz M. Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients. Med Oral Patol Oral Cir Bucal. 2011;16(7):e1036-42.
501			_aPMID:21743410
504			_aContiene 26 referencias
520			_aOBJECTIVE: To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer. STUDY DESIGN: This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiated as part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue, mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of the Mann-Whitney, Wilcoxon and chi-square tests. RESULTS: 70 patients were screened and 36 were included. The detection of Candida species in mucosa and tongue samples showed significant reductions in the test group. Total bacterial counts decreased in both groups from baseline to the 2-week visit, while minor changes occurred between 2 and 4 weeks (effects on P. gingivalis, P. intermedia, C. rectus, E. corrodens). CONCLUSIONS: Within the limitations of the small sample size, this study suggests that the use of the tested mouth-rinse may lead to improvements in microbiological parameters in patients irradiated for head-and-neck cancer.
710			_9302 _aServicio de Oncología Radioterápica
710			_9303 _aServicio de Oncología Médica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc5951.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c5951 _d5951