000 | 02727na a2200241 4500 | ||
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003 | H12O | ||
005 | 20180113070956.0 | ||
008 | 130622s2012 xxx||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_9582 _aBermejo Pareja, Félix _eNeurología |
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100 |
_aPuertas Martín, Verónica _91778 _eNeurología |
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245 | 0 | 0 |
_aCognitive features of essential tremor: a review of the clinical aspects and possible mechanistic underpinnings. _h[artículo] |
260 |
_bTremor and Other Hyperkinetic Movements, _c2012 |
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300 | _a2. pii: 02-74-541-1. | ||
500 | _aFormato Vancouver: Bermejo-Pareja F, Puertas-Martín V. Cognitive features of essential tremor: a review of the clinical aspects and possible mechanistic underpinnings. Tremor Other Hyperkinet Mov (N Y). 2012;2. pii: 02-74-541-1. | ||
501 | _aPMID: 23440004 | ||
504 | _aContiene 96 referencias | ||
520 | _aThe classical concept of essential tremor (ET) as a monosymptomatic tremorogenic disorder has been questioned in the last decade as new evidence has been described. Clinical, neuroimaging, and pathological studies have described a probable structural basis (mainly in cerebellum) and evidence that ET is associated with subtle clinical cerebellar deficits and several non-motor clinical manifestations, such as cognitive and mood disorders. We performed literature searches in Medline, ISI Web of Knowledge, and PsycInfo databases. The aim of this review is to describe cognitive deficits associated with ET. First, we present a brief history of ET cognitive disorders presented. Second, we describe several clinical cross-sectional series demonstrating that ET is associated with mild cognitive deficits of attention, executive functions, several types of memory (working memory, immediate, short term, delayed, and possibly others) and, mood disorders (depression). Recent neuroimaging studies favor a cerebellar basis for these cognitive deficits. Population-based surveys confirm that mild cognitive dysfunction is not limited to severe ET cases, the entire ET group, including mild and undiagnosed cases, can be affected. Cohort studies indicated that ET cognitive deficits could be progressive and that ET patients had an increased risk of dementia. The mood and cognitive deficits in ET are in agreement with cognitive affective cerebellar syndrome described in patients with cerebellar disorders. New evidence, mainly from functional (neuroimaging) and prospective clinical studies would further bolster recent descriptions of ET clinical manifestations. | ||
710 |
_9267 _aServicio de Neurología-Neurofisiología |
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856 |
_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572680/ _yAcceso libre |
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_n0 _2ddc _cART |
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999 |
_c5828 _d5828 |