000 02727na a2200241 4500
003 H12O
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008 130622s2012 xxx||||| |||| 00| 0 eng d
040 _cH12O
041 _aeng
100 _9582
_aBermejo Pareja, Félix
_eNeurología
100 _aPuertas Martín, Verónica
_91778
_eNeurología
245 0 0 _aCognitive features of essential tremor: a review of the clinical aspects and possible mechanistic underpinnings.
_h[artículo]
260 _bTremor and Other Hyperkinetic Movements,
_c2012
300 _a2. pii: 02-74-541-1.
500 _aFormato Vancouver: Bermejo-Pareja F, Puertas-Martín V. Cognitive features of essential tremor: a review of the clinical aspects and possible mechanistic underpinnings. Tremor Other Hyperkinet Mov (N Y). 2012;2. pii: 02-74-541-1.
501 _aPMID: 23440004
504 _aContiene 96 referencias
520 _aThe classical concept of essential tremor (ET) as a monosymptomatic tremorogenic disorder has been questioned in the last decade as new evidence has been described. Clinical, neuroimaging, and pathological studies have described a probable structural basis (mainly in cerebellum) and evidence that ET is associated with subtle clinical cerebellar deficits and several non-motor clinical manifestations, such as cognitive and mood disorders. We performed literature searches in Medline, ISI Web of Knowledge, and PsycInfo databases. The aim of this review is to describe cognitive deficits associated with ET. First, we present a brief history of ET cognitive disorders presented. Second, we describe several clinical cross-sectional series demonstrating that ET is associated with mild cognitive deficits of attention, executive functions, several types of memory (working memory, immediate, short term, delayed, and possibly others) and, mood disorders (depression). Recent neuroimaging studies favor a cerebellar basis for these cognitive deficits. Population-based surveys confirm that mild cognitive dysfunction is not limited to severe ET cases, the entire ET group, including mild and undiagnosed cases, can be affected. Cohort studies indicated that ET cognitive deficits could be progressive and that ET patients had an increased risk of dementia. The mood and cognitive deficits in ET are in agreement with cognitive affective cerebellar syndrome described in patients with cerebellar disorders. New evidence, mainly from functional (neuroimaging) and prospective clinical studies would further bolster recent descriptions of ET clinical manifestations.
710 _9267
_aServicio de Neurología-Neurofisiología
856 _uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572680/
_yAcceso libre
942 _n0
_2ddc
_cART
999 _c5828
_d5828