000			02079na a2200229 4500
003			H12O
005			20180417112606.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aCastellano, Daniel _9882 _eOncología Médica
245	0	0	_aGastroenteropancreatic neuroendocrine tumor cancer stem cells: do they exist?. _h[artículo]
260			_bCancer and Metastasis Reviews, _c2012
300			_a31(1-2):47-53.
500			_aFormato Vancouver: Grande E, Capdevila J, Barriuso J, Antón-Aparicio L, Castellano D. Gastroenteropancreatic neuroendocrine tumor cancer stem cells: do they exist?. Cancer Metastasis Rev. 2012 Jun;31(1-2):47-53.
501			_aPMID: 22105614
504			_aContiene 63 referencias
520			_aNeuroendocrine tumors (NETs) comprise a broad range of neoplasms that share biological and embryological origin. A deeper knowledge in the underlying molecular biology that results in the development and spread of NETs has allowed the use of novel-targeted therapies against angiogenesis and intracellular pathways, key checkpoints that govern growth, and proliferation of these tumors. Unfortunately, the possibility of cure is still far for patients with advanced stages. Cancer stem cells (CSCs) are present in most solid tumors. Nevertheless, there is limited evidence for the presence of CSCs in NETs. In this review, we will discuss the embryonic origin and possible existence of a gastroenteropancreatic neuroendocrine cancer stem cell. Here, we summarize the body of evidence supporting the presence of active embryological pathways like Notch, Wnt-beta-catenin, Hedgehog, or transforming growth factor-beta in NETs. New therapeutic approaches in the field of CSCs seem to have a clear role in the treatment of medulloblastomas and basal cell carcinomas, but their future value in other solid tumor types including NETs remains unclear.
710			_9303 _aServicio de Oncología Médica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc5448.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c5448 _d5448