| 000 | 02366na a2200229 4500 | ||
|---|---|---|---|
| 003 | PC5029 | ||
| 005 | 20180417112309.0 | ||
| 008 | 130622s2014 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_9539 _aRuilope Urioste, Luis Miguel _eNefrología |
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| 245 | 0 | 0 |
_aReview of blood pressure control rates and outcomes. _h[artículo] |
| 260 |
_bJournal of the American Society of Hypertension, _c2014 |
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| 300 | _a8(2):127-41. | ||
| 500 | _aFormato Vancouver: Bakris G, Sarafidis P, Agarwal R, Ruilope L. Review of blood pressure control rates and outcomes. J Am Soc Hypertens. 2014 Feb;8(2):127-41. | ||
| 501 | _aPMID: 24309125 | ||
| 504 | _aContiene 52 referencias | ||
| 520 | _aDespite the high prevalence of hypertension and documented benefits of blood pressure (BP) control, >40% of patients with hypertension are not controlled. A majority of uncontrolled hypertensive patients receive two or more antihypertensive drugs. The current review examined the relationship between antihypertensive combination drug therapy, achievement of goal BP, and cardiovascular (CV) outcomes. Articles were selected from a PubMed search using a prespecified search strategy. Randomized, controlled clinical trials of adult human subjects published in English between January 1991 and January 2013 were included. From 2319 identified articles, 28 met inclusion criteria and contained a total of 226,877 subjects. There were seven placebo-controlled studies and 21 treatment comparator and combination therapy studies. The studies included in this review reported a positive association between the degree of BP lowering, number of medications, and CV outcomes. As combination therapy became available, it was increasingly utilized in clinical trials and enabled an increased proportion of patients to achieve a prespecified BP target. Adverse events with monotherapy and combination therapy were as anticipated for the specific classes of antihypertensive therapy. Although many patients reach BP goal, combination antihypertensive therapy is often needed to reach BP goal. Effective BP lowering has been shown to result in improvements in CV outcomes. J Am Soc Hypertens 2014;8(2):127-141. | ||
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_986 _aServicio de Nefrología |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc5029.pdf _ySolicitar documento |
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_n0 _2ddc _cART |
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_c5029 _d5029 |
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