000			02981na a2200289 4500
003			H12O
005			20210625062801.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBenito León, Julián _9892 _eNeurología
100			_9582 _aBermejo Pareja, Félix _eNeurología
100			_aPosada Rodríguez, Ignacio Javier _91766 _e Neurología _e
100			_9715 _aTrincado Soriano, Rocío _eInstituto de Investigación i+12
100			_9423 _aVillarejo Galende, Alberto _eNeurología
245	0	0	_aMortality from Parkinson's disease: a population-based prospective study (NEDICES) _h[artículo]
260			_bMovement Disorders, _c2011
300			_a26(14):2522-2529.
500			_aFormato Vancouver: Posada IJ, Benito-León J, Louis ED, Trincado R, Villarejo A, Medrano MJ, Bermejo-Pareja F. Mortality from Parkinson's disease: a population-based prospective study (NEDICES). Mov Disord. 2011;26(14):2522-9.
501			_aPMID: 21915906
504			_aContiene 45 referencias
520			_aMost studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population-based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994-1995). Thirteen-year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow-up of 12.0 years (range, 0.04-14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80-2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32-2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40-4.90; P < .001). In this prospective population-based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality.
710			_9267 _aServicio de Neurología-Neurofisiología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/4/pc4976.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c4976 _d4976