000			02456na a2200277 4500
999			_c4793 _d4793
003			PC4793
005			20210625062801.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBenito León, Julián _9892 _eNeurología
100			_aBermejo Pareja, Félix _9582 _eNeurología
100			_aSánchez Ferro, Álvaro _91767 _eNeurología
100			_aTrincado Soriano, Rocío _9715 _eInstituto de Investigación i+12
100			_aVillarejo Galende, Alberto _9423 _eNeurología
245	0	0	_aRate of cognitive decline in premotor Parkinson's disease: A prospective study (NEDICES) _h[artículo]
260			_bMovement Disorders, _c2013
300			_a28(2):161-8.
500			_aFormato Vancouver: Sánchez-Ferro Á, Benito-León J, Louis ED, Mitchell AJ, Molina-Arjona JA, Trincado R et al. Rate of cognitive decline in premotor Parkinson's disease: a prospective study (NEDICES). Mov Disord. 2013 Feb;28(2):161-8.
501			_aPMID: 23239285
504			_aContiene 36 referencias
520			_aPrevious research has documented cognitive impairment in the early stages of Parkinson's disease (PD). It is not known when this decline starts or if decline progresses at an accelerated rate during the premotor period of the disorder. In this population-based prospective study of older people (65 years) from the Neurological Disorders in Central Spain (NEDICES) cohort, we compared the rates of cognitive decline in 3 groups: (1) non-PD elderly controls; (2) prevalent PD patients (those diagnosed with the disease at baseline, 199495); and (3) premotor PD subjects (those diagnosed with the disease at follow up, 199798, but not at baseline). A 37-item version of the MiniMental State Examination (37-MMSE) was administered in the 2 visits of the study. From 2487 participants (age, 72.8 +/- 6.0 years), including 2429 controls, we recruited 21 premotor PD cases, and 37 prevalent PD cases. At baseline, the mean 37-MMSE score was 28.5 +/- 4.7 in prevalent cases, 28.1 +/- 4.6 in premotor cases, and 29.9 +/- 5.0 in controls (P = .046). During the 3-year follow-up period, there was a significant score decline of 2.4 +/- 4.6 points in prevalent cases versus 0.2 +/- 4.1 points in premotor cases and 0.3 +/- 4.0 points in controls (KruskalWallis test, P = .03). In the NEDICES cohort, cognitive test scores of prevalent PD cases declined at a rate above and beyond that observed in premotor PD cases and in controls. The rate of cognitive decline in premotor PD and controls was similar. Our data suggest that a decline in global cognitive function does not occur in premotor PD.
710			_9267 _aServicio de Neurología-Neurofisiología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/4/pc4793.pdf _ySolicitar documento
942			_n0 _2ddc _cART