000			02899na a2200325 4500
999			_c4253 _d4253
003			PC4253
005			20191030062655.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng,spa
100			_aGuerrero Ramos, Félix _92375 _eUrología
100			_aLara Isla, Alba _92381 _eUrología
100			_aJusto Quintas, Juan _92382 _eUrología
100			_aDuarte Ojeda, José Manuel _91980 _eUrología
100			_aVillacampa Aubá, Felipe _9485 _eUrología
100			_91795 _aRosa Kehrman, Federico de la _eUrología
245	0	0	_aTratamiento adyuvante intravesical en cáncer de vejiga no músculo invasivo: importancia de la cepa y el mantenimiento. _h[artículo]
260			_bActas Urológicas Españolas, _c2017
300			_a41(9):590-595.
500			_aFormato Vancouver: Guerrero-Ramos F, Lara-Isla A, Justo-Quintas J, Duarte-Ojeda JM, de la Rosa-Kehrmann F, Villacampa-Aubá F. Tratamiento adyuvante intravesical en cáncer de vejiga no músculo invasivo: importancia de la cepa y el mantenimiento. Actas Urol Esp. 2017 Nov;41(9):590-595.
501			_aPMID: 28457495
504			_aContiene 15 referencias
520			_aBACKGROUND AND OBJECTIVE: Intravesical Bacille Calmette-Guérin (BCG) is essential for preventing the recurrence and progression of superficial bladder tumours. The aim of our study was to compare the efficacy and toxicity of the Connaught and Tice strains, as well as the importance of the maintenance regimen. MATERIAL AND METHODS: We retrospectively reviewed 110 patients with superficial bladder tumours who underwent adjuvant endovesical treatment. The patients were distributed into 3 groups, based on whether the treatment was with the Connaught strain, the Tice strain or both sequentially. We calculated the relapse-free survival rate in each group and compared the patients who completed the maintenance treatments against those who did not. To identify the predictors of relapse, we performed a multivariate analysis. We also assessed the toxicity by analysing the onset of BCGitis, urinary urgency, fever, urinary tract infection and treatment withdrawing due to adverse effects. RESULTS: We found no differences in the efficacy parameters. The patients in the Connaught group completed the maintenance to a lesser extent (38.4 vs. 72% for the Tice group and 76.3% for both groups; P=.010). The patients who completed the maintenance had better relapse-free survival at 60 months (88.5 vs. 74.2%; P=.036), regardless of the strain employed. The multivariate analysis identified a size larger than 3cm, more than 3 implants and not completing the maintenance as risk factors of relapse. The patients with the Connaught strain had higher rates of BCGitis, with no differences in the other events studied. CONCLUSION: Completing the maintenance phase is essential, regardless of the strain employed. The Connaught strain has a greater risk of BCGitis, and a sequential regimen could be useful in certain scenarios.
710			_9220 _aServicio de Urología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/4/pc4253.pdf _ySolicitar documento
942			_n0 _2ddc _cART