| 000 | 02131na a2200325 4500 | ||
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| 999 |
_c4233 _d4233 |
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| 003 | PC4233 | ||
| 005 | 20210625062801.0 | ||
| 008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_aDelgado Vázquez, Rafael _91016 _eMicrobiología y Parasitología |
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| 100 |
_aMartínez Prats, Lorena _91612 _eMicrobiología y Parasitología |
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| 245 | 0 | 0 |
_aIdentification of a Cluster of HIV-1 Controllers Infected with Low Replicating Viruses. _h[artículo] |
| 260 |
_bPlos One, _c2013 |
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| 300 | _a8(10):e77663. | ||
| 500 | _aFormato Vancouver: Casado C, Pernas M, Sandonis V, Alvaro-Cifuentes T, Olivares I, Fuentes R et al. Identification of a cluster of HIV-1 controllers infected with low replicating viruses. PLoS One. 2013 Oct 30;8(10):e77663. | ||
| 501 | _aPMID: 24204910 | ||
| 504 | _aContiene 63 referencias | ||
| 520 | _aLong term non-progressor patients (LTNPs) are characterized by the natural control of HIV-1 infection. This control is related to host genetic, immunological and virological factors. In this work, phylogenetic analysis of the proviral nucleotide sequences in env gene from a Spanish HIV-1 LTNPs cohort identified a cluster of 6 HIV-1 controllers infected with closely-related viruses. The patients of the cluster showed common clinical and epidemiological features: drug user practices, infection in the same city (Madrid, Spain) and at the same time (late 70's-early 80's). All cluster patients displayed distinct host alleles associated with HIV control. Analysis of the virus envelope nucleotide sequences showed ancestral characteristic, lack of evolution and presence of rare amino-acids. Biological characterization of recombinant viruses with the envelope proteins from the cluster viruses showed very low replicative capacity in TZMbl and U87-CD4/CCR5 cells. The lack of clinical progression in the viral cluster patients with distinct combinations of protective host genotypes, but infected by low replicating viruses, indicate the important role of the virus in the non-progressor phenotype in these patients. | ||
| 710 |
_981 _aServicio de Microbiología y Parasitología |
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| 710 |
_9625 _aInstituto de Investigación imas12 |
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| 856 |
_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813686/pdf/pone.0077663.pdf _yAcceso libre |
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| 942 |
_n0 _2ddc _cART |
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