000			02630na a2200277 4500
999			_c4050 _d4050
003			PC4050
005			20200312120945.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aJiménez Arriero, Miguel Ángel _9656 _ePsiquiatría
245	0	0	_aPatterns of pharmacological maintenance treatment in a community mental health services bipolar disorder cohort study (SIN-DEPRES). _h[artículo]
260			_bInternational Journal of Neuropsychopharmacology, _c2013
300			_a16(3):513-23.
500			_aFormato Vancouver: Grande I, de Arce R, Jiménez-Arriero MÁ, Lorenzo FG, Valverde JI, Balanzá-Martínez V et al. SIN-DEPRES Group. Patterns of pharmacological maintenance treatment in a community mental health services bipolar disorder cohort study (SIN-DEPRES). Int J Neuropsychopharmacol. 2013 Apr;16(3):513-23.
501			_aPMID: 22717099
504			_aContiene 49 referencias
520			_aMaintenance therapy in bipolar disorder (BD) is usually required to prevent relapses and improve residual symptoms. Therefore, in this study, we describe patterns of pharmacological maintenance treatment and identify associated clinical features. This prospective multicentre epidemiological study recruited a cohort of 739 consecutive out-patients with clinically stable BD. Clinical stability was assessed at baseline with the Clinical Global Impression scale for BD and depressive symptoms with the Hamilton Depression Rating Scale. Psychotropic medications were classified and analysed according to their mechanism as well as use. Logistic regression models were used to examine the associations between pharmacological strategies and clinical features. Longer time since last episode [odds ratio (OR) 1.002, p<0.0001] and family history of psychiatric disorders (OR 1.911, p=0.028) were associated with lithium in monotherapy; manic polarity of the most recent episode (OR 3.300, p=0.006) and longer duration of clinical stability (OR 1.009, p=0.034) with antipsychotic in monotherapy; depressive polarity of the most recent episode (OR 2.567, p=0.003) and bipolar II disorder diagnosis (OR 2.278, p=0.008) with antidepressant combination; no ongoing psychiatric co-morbidity (OR 0.230, p=0.004) with lithium and anticonvulsant; manic polarity of the most recent episode (OR 3.774, p<0.0001) with lithium and antipsychotic; manic polarity of the most recent episode (OR 2.907, p=0.028) with lithium, anticonvulsant and antipsychotic. The pharmacological patterns followed published recommendations, except for the excessive use of antidepressants. This study reveals clinical factors closely related to prescription patterns.
710			_9150 _aServicio de Psiquiatría
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/4/pc4050.pdf _ySolicitar documento
942			_n0 _2ddc _cART