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008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aspa
100			_9876 _aAguado García, José María _eEnfermedades Infecciosas
100			_9211 _aÁlvarez de Miguel, Florencio _eMedicina Interna
100			_9263 _aFernández Ruiz, Mario _eMedicina Interna
245	0	0	_aHierro e infección fúngica invasora. _h[artículo]
260			_bRevista iberoamericana de micología, _c2013
300			_a30(4):217-25.
500			_aFormato Vancouver: Álvarez F, Fernández-Ruiz M, Aguado JM.Hierro e infección fúngica invasora. Rev Iberoam Micol. 2013 Oct-Dec;30(4):217-25.
501			_aPMID: 23684655
504			_aContiene 89 referencias
520			_aIron is an essential factor for both the growth and virulence of most of microorganisms. As a part of the innate (or nutritional) immune system, mammals have developed different mechanisms to store and transport this element in order to limit free iron bioavailability. To survive in this hostile environment, pathogenic fungi have specific uptake systems for host iron sources, one of the most important of which is based on the synthesis of siderophores-soluble, low-molecular-mass, high-affinity iron chelators. The increase in free iron that results from iron-overload conditions is a well-established risk factor for invasive fungal infection (IFI) such as mucormycosis or aspergillosis. Therefore, iron chelation may be an appealing therapeutic option for these infections. Nevertheless, deferoxamine -the first approved iron chelator- paradoxically increases the incidence of IFI, as it serves as a xeno-siderophore to Mucorales. On the contrary, the new oral iron chelators (deferiprone and deferasirox) have shown to exert a deleterious effect on fungal growth both in vitro and in animal models. The present review focuses on the role of iron metabolism in the pathogenesis of IFI and summarises the preclinical data, as well as the limited clinical experience so far, in the use of new iron chelators as treatment for mucormycosis and invasive aspergillosis.
710			_96 _aServicio de Medicina Interna
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3518.pdf _ySolicitar documento
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999			_c3518 _d3518