000			01878na a2200241 4500
999			_c3484 _d3484
003			H12O
005			20190820130226.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_983 _aMorales Ruiz, Enrique _eNefrología
100			_aPraga Terente, Manuel _91488 _eNefrología
245	0	4	_aThe effect of weight loss in obesity and chronic kidney disease. _h[artículo]
260			_bCurrent Hypertension Reports, _c2012
300			_a14(2):170-6.
500			_aFormato Vancouver: Morales E, Praga M. The effect of weight loss in obesity and chronic kidney disease. Curr Hypertens Rep. 2012 Apr;14(2):170-6.
501			_aPMID: 22258314
504			_aContiene 51 referencias
520			_aSeveral epidemiologic investigations have confirmed that obesity is a significant risk factor for the appearance of proteinuria and end-stage kidney disease in a normal population. Weight loss induced by low-calorie diets, physical exercise, or bariatric surgery is accompanied by an important antiproteinuric effect. Reduction in proteinuria is already observed after a few weeks from the onset of weight loss and it is evident even in patients with modest weight losses. Reduction in proteinuria by weight loss has been described in chronic proteinuric nephropathies of different etiologies. The mechanisms through which weight loss may reverse proteinuria are likely to be plural: better control of blood pressure, improvement of serum lipid profile, improvement of insulin sensitivity, better glycemic control in diabetes patients, decrease of circulating leptin levels, reversal of glomerular hyperfiltration, and decreased activation of the renin-angiotensin-aldosterone system.
710			_986 _aServicio de Nefrología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3484.pdf _ySolicitar documento
942			_n0 _2ddc _cART