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| 003 | H12O | ||
| 005 | 20180417112255.0 | ||
| 008 | 130622s2012 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_9162 _aLópez Medrano, Francisco _eEnfermedades Infecciosas |
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| 245 | 0 | 0 |
_aImmunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection _h[artículo] |
| 260 |
_bEuropean Journal of Clinical Microbiology & Infectious Diseases, _c2012 |
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| 300 | _a31(4):547-56. | ||
| 500 | _aFormato Vancouver: Cordero E, Aydillo T, Fariñas MC, Paño-Pardo JR, Pachón J, Viasus D, et al. Immunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection. Eur J Clin Microbiol Infect Dis. 2012 Apr;31(4):547-56. | ||
| 501 | _aPMID: 21792558 | ||
| 504 | _aContiene 25 referencias | ||
| 520 | _aThe purpose of this paper was to prospectively characterize the clinical manifestations and outcomes of confirmed influenza A 2009 (H1N1) virus infection in immunosuppressed patients with hospital admission and compare them with those of a general population. A multicenter prospective cohort study was carried out. All adult patients admitted to 13 hospitals in Spain with confirmed influenza A 2009 (H1N1) virus infection from June 12, 2009 to November 11, 2009 were included. Risk factors for complicated influenza infection were studied in immunosuppressed patients. Overall, 559 patients were included, of which 56 were immunosuppressed, nine with solid or hematological malignancies, 18 with solid-organ transplant recipients, 13 with corticosteroid therapy, and six with other types of immunosuppression. Clinical findings at diagnosis were similar in both groups. Nineteen immunosuppressed patients had pneumonia (33.9%). Immunosuppressed patients with pandemic influenza had bacterial co-infection more frequently (17.9% vs. 6.4%, p = 0.02), specifically, gram-negative bacilli and Staphylococcus aureus infections. Mortality was higher in immunosuppressed patients (7.1% vs. 1.8%, p < 0.05). The only modifiable risk factor of complicated influenza A 2009 (H1N1) was delayed antiviral therapy. In immunosuppressed patients, influenza A 2009 (H1N1) virus infection has higher mortality than in non-immunosuppressed individuals. Bacterial co-infection is common in complicated cases. | ||
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_96 _aServicio de Medicina Interna |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3335.pdf _ySolicitar documento |
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_n0 _2ddc _cART |
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_c3335 _d3335 |
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