000 | 01805na a2200229 4500 | ||
---|---|---|---|
999 |
_c3284 _d3284 |
||
003 | PC3284 | ||
005 | 20180417112254.0 | ||
008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_aCiruelos Gil, Eva María _91082 _eOncología Médica |
||
100 |
_aCortés-Funes Castro, Hernán _91181 _eOncología Médica |
||
100 |
_aGhanem Cañete, Ismael _91793 _eOncología Médica |
||
100 |
_aManso Sánchez, Luis _9432 _eOncología Médica |
||
245 | 0 | 0 |
_aRole of inhibitors of mammalian target of rapamycin in the treatment of luminal breast cancer. _h[artículo] |
260 |
_bAnti-Cancer Drugs, _c2013 |
||
300 | _a24(8):769-80. | ||
500 | _aFormato Vancouver: Ciruelos E, Cortés-Funes H, Ghanem I, Manso L, Arteaga C. Role of inhibitors of mammalian target of rapamycin in the treatment of luminal breast cancer. Anticancer Drugs. 2013 Sep;24(8):769-80. | ||
501 | _aPMID: 23838677 | ||
504 | _aContiene 75 referencias | ||
520 | _aApproximately 75% of patients with breast cancer present hormone receptor-positive tumors. This subtype of breast cancer initially shows a high overall response rate to hormonal treatments. However, resistance eventually develops, resulting in tumor progression. The PI3K/Akt/mTOR pathway regulates several cellular functions in cancer such as cell growth, survival, and proliferation. In addition, a high activation level of the PI3K/Akt/mTOR pathway is related to resistance to conventional chemotherapy and hormone therapy. The mTOR inhibitor everolimus, in combination with hormonal treatments, has led to excellent results in progression-free survival in patients with metastatic breast cancer resistant to hormone therapies. Therefore, everolimus has entered the National Comprehensive Cancer Network (NCCN) guidelines 2012 and its combination with exemestane was approved recently by the US Food and Drug Administration and the European Medicines Agency. This is the first time that a drug will have been approved for the restoration of hormone sensitivity in breast cancer. | ||
710 |
_9303 _aServicio de Oncología Médica |
||
856 |
_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3284.pdf _ySolicitar documento |
||
942 |
_n0 _2ddc _cART |