000			01455na a2200265 4500
999			_c2864 _d2864
003			PC2864
005			20210625062758.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aCuezva, J.M. _91891 _eInstituto de Investigación i+12
100			_aSánchez Aragó, María _91906 _eInstituto de Investigación i+12
245	0	0	_aDegradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells. _h[artículo]
260			_bEMBO reports, _c2013
300			_a14(7):638-44.
500			_aFormato Vancouver: Sánchez-Aragó M, García-Bermúdez J, Martínez-Reyes I, Santacatterina F, Cuezva JM. Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells. EMBO Rep. 2013 Jul;14(7):638-44.
501			_aPMID: 23722655
504			_aContiene 19 referencias
520			_aDifferentiation of human mesenchymal stem cells (hMSCs) requires the rewiring of energy metabolism. Herein, we demonstrate that the ATPase inhibitory factor 1 (IF1) is expressed in hMSCs and in prostate and colon stem cells but is not expressed in the differentiated cells. IF1 inhibits oxidative phosphorylation and regulates the activity of aerobic glycolysis in hMSCs. Silencing of IF1 in hMSCs mimics the metabolic changes observed in osteocytes and accelerates cellular differentiation. Activation of IF1 degradation acts as the switch that regulates energy metabolism during differentiation. We conclude that IF1 is a stemness marker important for maintaining the quiescence state.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701239/ _yAcceso libre
942			_n0 _2ddc _cART