000			03071na a2200337 4500
003			PC2698
005			20180417112248.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aManzanares López-Manzanares, Javier _91165 _ePediatría
100			_aMedina Benítez, Enrique _91167 _ePediatría
100			_aMeneu Díaz, Juan Carlos _91087 _eCirugía General y del Aparato Digestivo
100			_aMora Diaz, Sergio _91986 _eInmunología
100			_9576 _aMorales Cerdán, José María _eNefrología
100			_aPaz Artal, Estela _91510 _eInmunología
100			_9661 _aSerrano Hernández, Antonio _eInmunología
245	0	0	_aClinical value of a single determination of intracellular ATP levels in stimulated CD4+ T lymphocytes in pediatric patients with stable liver transplantation _h[artículo]
260			_bTransplantation Proceedings, _c2012
300			_a44(9):2622-2624.
500			_aFormato Vancouver: Serrano M, Meneu JC, Medina E, Alfaro FJ, Martínez-Flores JA, Mora S, et al. Clinical value of a single determination of intracellular ATP levels in stimulated CD4+ T lymphocytes in pediatric patients with stable liver transplantation. Transplant Proc. 2012;44(9):2622-4.
501			_aPMID: 23146475
504			_aContiene 8 referencias
520			_aIn the follow-up of transplanted patients under immunosupression, the functional assessment of CD4+ T cells activation by measuring intracellular ATP levels in vitro, using the Immuknow test give information on how immune system is functioning. Therefore, it has been reported that low levels of ATP correlate with the risk of opportunistic infection. Although limited, comprehensive results in adult recipients as well as in pediatric transplanted patients have been reported. Forty stable liver pediatric transplanted patients (mean age: 11.0 years [SD 5.65]), within at least 1 year of transplant were selected for a scheduled review, and an unique determination of Immuknow was performed. Average ATP levels were 317 ng/mL (200-400 ng/mL) which were similar to the values observed in adult population. ATP values among patients with monotherapy Cyclosporin A (CSA) or tacrolimus (TAC) were significantly higher (P = .005) than in patients with double immunosupressive therapy using either CSA/TAC + Mycophenolate Mofetil (MMF). In CSA treatment, there are significant differences (P = .0003) between monotherapy and double therapy, but in the case of TAC we did not find differences (P > .1). A single determination of levels of ATP on CD4+ lymphocytes, can provide additional information that could be used as a complementary test to guide immunosuppressive therapy in paediatric liver transplant recipients.
710			_9446 _aServicio de Pediatría-Neonatología
710			_9395 _aServicio de Inmunología
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
710			_986 _aServicio de Nefrología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/2/pc2698.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c2698 _d2698