000			02766na a2200289 4500
003			PC2428
005			20180417112246.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBarrios López, Marta _91175 _ePediatría
100			_978 _aChaves Sánchez, Fernando _eMicrobiología y Parasitología
100			_aGómez-González, Carmen _92360 _eMicrobiología y Parasitología
100			_91619 _aOrellana Miguel, María Ángeles _eMicrobiología y Parasitología
100			_9443 _aRojo Conejo, Pablo _ePediatría
245	0	0	_aStaphylococcus aureus abscesses: methicillin-resistance or Panton-Valentine leukocidin presence?. _h[artículo]
260			_bArchives of disease in childhood, _c2013
300			_a98(8):608-10.
500			_aFormato Vancouver: Barrios López M, Gómez González C, Orellana MÁ, Chaves F, Rojo P. Staphylococcus aureus abscesses: methicillin-resistance or Panton-Valentine leukocidin presence? Arch Dis Child. 2013 Aug;98(8):608-10.
501			_aPMID: 23728388
504			_aContiene 11 referencias
520			_aPanton-Valentine leukocidin (PVL) is a toxin associated with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) worldwide and also occurs in community-associated methicillin-susceptible S aureus (CA-MSSA) strains. The aims of the study were to determine the prevalence of PVL in community-onset S aureus skin and soft-tissue infections (SSTIs) and to analyse the influence of methicillin resistance and PVL presence on the clinical characteristics of these infections. PATIENTS AND METHODS: We prospectively enrolled all children with S aureus community-onset SSTIs attending the emergency department of a tertiary hospital between 2007 and 2009. Results A total of 142 S aureus SSTIs were identified, 46 (32%) were PVL positive. The proportion of subjects in each group was: 89 (63%) PVL-MSSA, 33 (23%) PVL+MSSA, 13 (9%) PVL+MRSA and 7 (5%) PVL-MRSA. PVL+infections were more frequently abscesses (63% vs 39%, p<0.01), and more often required incision and drainage (p<0.01) and hospital admission (46% vs 26%, p=0.02). MRSA infections were also more frequently associated with abscesses but in a multivariable analysis only PVL remained independently related (OR 2.33; 95% CI 1.10 to 4.90). CONCLUSIONS: Our study found a high prevalence of PVL presence in community-onset S aureus SSTIs in children in Spain. This toxin is associated with more abscess formation, regardless of methicillin resistance.
710			_981 _aServicio de Microbiología y Parasitología
710			_9446 _aServicio de Pediatría-Neonatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/2/pc2428.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c2428 _d2428