000			02669na a2200229 4500
003			PC2249
005			20180417112244.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9441 _aUrruzuno Tellería, Pedro _ePediatría
245	0	0	_aHelicobacter pylori Infection in European Children with Gastro-duodenal Ulcers and Erosions. _h[artículo]
260			_bPediatric Infectious Disease Journal, _c2013
300			_a;32(12):1324-9.
500			_aFormato Vancouver: Bontems P, Kalach N, Vanderpas J, Iwanczak B, Casswall T, Koletzko S et al. Helicobacter pylori Infection in European children with gastro-duodenal ulcers and erosions. Pediatr Infect Dis J. 2013 Dec;32(12):1324-9.
501			_aPMID: 24569306
504			_aContiene 26 referencias
520			_aBackground: To analyze risk factors associated with gastro-duodenal ulcers and erosions in children. Methods: Open, prospective, multicenter, case-control study carried out in 11 European countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. Logistic regression models were performed with adjustment for centers and age groups. Results: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). Independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P < 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). Exposure factors for duodenal ulcers were H. pylori infection (P < 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). No risk factor was identified in 97/202 (48.0%) cases. Conclusions:H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. No risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.
710			_9446 _aServicio de Pediatría-Neonatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/2/pc2249.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c2249 _d2249