000			nab a22 7a 4500
999			_c17977 _d17977
003			PC17977
005			20250602124328.0
008			250602b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9892 _aBenito León, Julián _eNeurología
100			_9309 _aLabiano Fontcuberta, Andrés _eNeurología
245	0	0	_aLinking Essential Tremor to the Cerebellum: Clinical Evidence. _h[revisión]
260			_bCerebellum (London, England); _c2016
300			_a15(3):253-62.
500			_aFormato Vancouver: Benito León J, Labiano Fontcuberta A. Linking Essential Tremor to the Cerebellum: Clinical Evidence. Cerebellum. 2016 Jun;15(3):253-62.
501			_aPMID: 26521074
504			_aContiene 100 referencias
520			_aEssential tremor (ET) might be a family of diseases unified by the presence of kinetic tremor, but also showing etiological, pathological, and clinical heterogeneity. In this review, we will describe the most significant clinical evidence, which suggests that ET is linked to the cerebellum. Data for this review were identified by searching PUBMED (January 1966 to May 2015) crossing the terms "essential tremor" (ET) and "cerebellum," which yielded 201 entries, 11 of which included the term "cerebellum" in the article title. This was supplemented by articles in the author's files that pertained to this topic. The wide spectrum of clinical features of ET that suggest that it originates as a cerebellar or cerebellar outflow problem include the presence of intentional tremor, gait and balance abnormalities, subtle features of dysarthria, and oculomotor abnormalities, as well as deficits in eye-hand coordination, motor learning deficits, incoordination during spiral drawing task, abnormalities in motor timing and visual reaction time, impairment of social abilities, improvement in tremor after cerebellar stroke, efficacy of deep brain stimulation (which blocks cerebellar outflow), and cognitive dysfunction. It is unlikely, however, that cerebellar dysfunction, per se, fully explains ET-associated dementia, because the cognitive deficits that have been described in patients with cerebellar lesions are generally mild. Overall, a variety of clinical findings suggest that in at least a sizable proportion of patients with ET, there is an underlying abnormality of the cerebellum and/or its pathways.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17977.pdf _ySolicitar documento
942			_2ddc _cREV _n0