000			nab a22 7a 4500
999			_c17976 _d17976
003			PC17976
005			20250602122731.0
008			250602b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92564 _aRiveiro Falkenbach, Erica _eInstituto de Investigación i+12
100			_91223 _aOrtiz Romero, Pablo Luis _eDermatología Médico-Quirúrgica y Venereología
100			_91219 _aRodríguez Peralto, José Luis _eAnatomía Patológica
245	0	0	_aLineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers. _h[artículo]
260			_bNature communications, _c2016
300			_a7:13418.
500			_aFormato Vancouver: Pérez Guijarro E, Karras P, Cifdaloz M, Martínez Herranz R, Cañón E, Graña O et al. Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers. Nat Commun. 2016 Nov 18;7:13418.
501			_aPMID: 27857118 PMC5120223
504			_aContiene 70 referencias
520			_aNuclear 3'-end-polyadenylation is essential for the transport, stability and translation of virtually all eukaryotic mRNAs. Poly(A) tail extension can also occur in the cytoplasm, but the transcripts involved are incompletely understood, particularly in cancer. Here we identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma. CPEB4 is upregulated early in melanoma progression, as defined by computational and histological analyses. Melanoma cells are distinct from other tumour cell types in their dependency on CPEB4, not only to prevent mitotic aberrations, but to progress through G1/S cell cycle checkpoints. RNA immunoprecipitation, sequencing of bound transcripts and poly(A) length tests link the melanoma-specific functions of CPEB4 to signalling hubs specifically enriched in this disease. Essential in these CPEB4-controlled networks are the melanoma drivers MITF and RAB7A, a feature validated in clinical biopsies. These results provide new mechanistic links between cytoplasmic polyadenylation and lineage specification in melanoma.
710			_9625 _aInstituto de Investigación imas12
710			_9145 _aServicio de Dermatología Médico-Quirúrgica y Venereología
710			_9330 _aServicio de Anatomía Patológica
856			_uhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5120223/pdf/ncomms13418.pdf _yAcceso libre
942			_2ddc _cART _n0