000			nab a22 7a 4500
999			_c17907 _d17907
003			PC17907
005			20240812132457.0
008			240812b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_942 _aFerrero Herrero, Eduardo _eCirugía General y del Aparato Digestivo
100			_9510 _aMoreno González, Enrique _eCirugía General y del Aparato Digestivo
245	0	0	_aImpact of Histological Factors of Hepatocellular Carcinoma on the Outcome of Liver Transplantation. _h[artículo]
260			_bTransplantation proceedings, _c2016
300			_a48(6):1968-77.
500			_aFormato Vancouver: Donat M, Alonso S, Pereira F, Ferrero E, Carrión L, Acin Gándara D et al. Impact of Histological Factors of Hepatocellular Carcinoma on the Outcome of Liver Transplantation. Transplant Proc. 2016 Jul-Aug;48(6):1968-77.
501			_aPMID: 27569930
504			_aContiene 73 referencias
520			_aBackground: The aim of this study was to identify predictors of overall survival (OS), disease-free survival (DFS), and recurrence in a cohort of 151 patients with hepatocellular carcinoma (HCC) and cirrhosis who were treated by liver transplantation (LT). Patients and methods: A retrospective database of patients undergoing LT for radiologically diagnosed HCC at "12 de Octubre" Hospital, Madrid during 1986-2006 was analyzed. Results: The median follow-up was 67.44 months (SD = 55.7 months). Overall 1-, 3-, 5-, and 10-year survival was 87.5%, 73.7%, 64.1% and 43.4%, respectively. The 5-year OS of patients beyond the Milan criteria was 47.14%, whereas that of patients within the Milan criteria was 70.13% (P = .011). The 5-year OS of patients beyond the Milan criteria and with microvascular invasion (MVI) was 27.27%, whereas that of patients beyond the Milan criteria and without MVI criteria was 57.89% (P = .003). Multivariate analysis of prognostic factors revealed MVI and G3 to be independent and statistically significant factors affecting OS (P < .0001 and P = .045, respectively), DFS (P < .0001 and P = .004, respectively), and recurrence (P = .0002 and P = .028, respectively). Multivariate analysis of prognostic factors also revealed preoperative fine-needle aspiration (FNA) to be an independent negative statistically significant factor affecting recurrence (P = .0022). Multivariate analysis of predictive MVI factors revealed preoperative α-fetoprotein (AFP) levels >200 ng/mL to be an independent positive and statistically significant predictor of MVI (P = .0004). Conclusion: MVI and G3 are independent negative factors affecting OS, DFS, and recurrence. The presence of MVI or AFP levels >200 ng/mL represent a contraindication for LT, as long as the patient is beyond the Milan criteria.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17907.pdf _ySolicitar documento
942			_2ddc _cART _n0