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999			_c17896 _d17896
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008			240705b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91883 _aUsátegui Corral, Alicia _eInstituto de Investigación i+12
100			_92671 _aFaré García, Regina _eInstituto de Investigación i+12
100			_91010 _aPablos Álvarez, José Luis _eReumatología
245	0	0	_aImmunopathologic characterization of ultrasound-defined synovitis in rheumatoid arthritis patients in clinical remission. _h[artículo]
260			_bArthritis research & therapy, _c2016
300			_a18:74.
500			_aFormato Vancouver: Ramírez J, Celis R, Usategui A, Ruiz Esquide V, Faré R, Cuervo A et al. Immunopathologic characterization of ultrasound-defined synovitis in rheumatoid arthritis patients in clinical remission. Arthritis Res Ther. 2016 Mar 31;18:74.
501			_aPMID: 27036513 PMC481845
504			_aContiene 35 referencias
520			_aBackground: Patients with rheumatoid arthritis (RA) in clinical remission may have ultrasound-defined synovitis according to the presence of power Doppler (PD) signal. The objective was to describe the immunopathologic characteristics of ultrasound-defined synovitis compared with synovitis in patients with clinically active RA. Methods: We included between 6 and 8 ultrasound-guided synovial biopsies per patient from 20 patients with RA in clinical remission (DAS28-ESR <2.6) with PD signal, 22 synovial tissue samples (ST) from patients with clinically active RA (swollen joint with confirmed inflammatory synovial fluid) as inflammatory controls, and 10 ST from non-inflammatory controls. Immunostaining for CD3 (T lymphocytes), CD20 (B lymphocytes), CD68 (macrophages), CD117 (mast cells), hsp47 (fibroblasts), bFGF and CXCL12 (angiogenic factors) was made and quantified by digital image analysis. The number of CD31 vessels/mm(2) was quantified. Results: RA patients in remission with PD signal had significantly reduced synovial T-cell, B-cell, mast cell and fibroblast density, but similar macrophage infiltration compared with patients with clinically active RA. Vascularity, bFGF and CXCL12 were partially reduced in RA patients in remission with PD signal compared to those with active RA, but were significantly higher compared with ST from non-inflammatory controls. During the 12-month follow up, 8/20 RA patients (40 %) lost remission: all had synovial hypertrophy grade ≥2 and significantly more synovial B cells and mast cells than patients maintaining remission. Conclusions: Asymptomatic ultrasound-defined synovitis and clinically active arthritis differ in the degree of infiltrating lymphoid, mast cells and fibroblast density, but are similar with respect to macrophage infiltration. Persistently increased angiogenic factor expression and vascularity may explain the persistence of a PD signal.
710			_9123 _aServicio de Reumatología
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818452/pdf/13075_2016_Article_970.pdf _yAcceso libre
942			_2ddc _cART _n0