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008			240702b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93261 _aMartínez de Toda, Irene _eInstituto de Investigación imas12
100			_93416 _aMaté, Ianire _eInstituto de Investigación imas12
100			_93410 _aVida, Carmen _eInstituto de Inestigación imas12
100			_93417 _aCruces, Julia _eInstituto de Investigación imas12
100			_93411 _aFuente, Mónica de la _eInstituto de Investigación imas12
245	0	0	_aImmune function parameters as markers of biological age and predictors of longevity. _h[artículo]
260			_bAging, _c2016
300			_a8(11):3110-9.
500			_aFormato Vancouver. Martínez de Toda I, Maté I, Vida C, Cruces J, De la Fuente M. Immune function parameters as markers of biological age and predictors of longevity. Aging (Albany NY). 2016 Nov 28;8(11):3110-9.
501			_aPMID: 27899767 PMC5191888
504			_aContiene 40 referencias
520			_aChronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the biological age has been a challenge both for research and clinical studies. The aim was to identify and validate several immune cell function parameters as markers of biological age. Adult, mature, elderly and long-lived human volunteers were used. The chemotaxis, phagocytosis, natural killer activity and lymphoproliferation in neutrophils and lymphocytes of peripheral blood were analyzed. The same functions were measured in peritoneal immune cells from mice, at the corresponding ages (adult, mature, old and long lived) in a longitudinal study. The results showed that the evolution of these functions was similar in humans and mice, with a decrease in old subjects. However, the long-lived individuals maintained values similar to those in adults. In addition, the values of these functions in adult prematurely aging mice were similar to those in chronologically old animals, and they died before their non-prematurely aging mice counterparts. Thus, the parameters studied are good markers of the rate of aging, allowing the determination of biological age.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191888/pdf/aging-08-3110.pdf _yAcceso libre
942			_2ddc _cART _n0