000			nab a22 7a 4500
999			_c17889 _d17889
003			PC17889
005			20240701114256.0
008			240701b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91875 _aSanz Fuentenebro, Francisco Javier _ePsiquiatría
245	0	0	_aIdentification of two clusters within schizophrenia with different structural, functional and clinical characteristics. _h[artículo]
260			_bProgress in neuro-psychopharmacology & biological psychiatry, _c2016
300			_a64:79-86.
500			_aFormato Vancouver: Lubeiro A, Rueda C, Hernández JA, Sanz J, Sarramea F, Molina V. Identification of two clusters within schizophrenia with different structural, functional and clinical characteristics. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:79-86.
501			_aPMID: 26216861
504			_aContiene 40 referencias
520			_aBackground: Several biologically distinct subgroups may coexist within schizophrenia, which may hamper the necessary replicability to translate research findings into clinical practice. Methods: Cortical thickness, curvature and area values and subcortical volumes of 203 subjects (121 schizophrenia patients, out of which 64 were first episodes), 60 healthy controls and 22 bipolar patients were used to identify clusters using principal components and canonical discriminant analyses. Regional glucose metabolism using positron emission tomography, P300 event related potential, baseline clinical data and percentage of improvement with treatment were used to validate possible clusters based on MRI data. Results: All the controls, the bipolar patients and most of the schizophrenia patients were grouped in a cluster (cluster A). A group of 24 schizophrenia patients (12 first episodes), characterized by large intrinsic curvature values, was identified (cluster B). These patients, but not those in cluster A, showed reduced thalamic and cingulate glucose metabolism in comparison to controls, as well as a worsening of negative symptoms at follow-up. Patients in cluster A showed a significant putaminal metabolic increase, which was not observed for those in cluster B. P300 amplitude was reduced in patients of both clusters, in comparison to controls. Conclusions: Results of this study support the existence of a biologically distinct group within the schizophrenia syndrome, characterized by increased cortical curvature values, reduced thalamic and cingulate metabolism, lack of the expected increased putaminal metabolism with antipsychotics and persistent negative symptoms.
710			_9150 _aServicio de Psiquiatría
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17889.pdf _ySolicitar documento
942			_2ddc _cART _n0