000			nab a22 7a 4500
999			_c17881 _d17881
003			PC17881
005			20240624132240.0
008			240621b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93261 _aMartínez de Toda, Irene _eInstituto de Investigación imas12
100			_93410 _aVida, Carmen _eInstituto de Inestigación imas12
100			_93411 _aFuente, Mónica de la _eInstituto de Investigación imas12
245	0	0	_aHsp70 basal levels, a tissue marker of the rate of aging and longevity in mice. _h[artículo]
260			_bExperimental gerontology, _c2016
300			_a84:21-28.
500			_aFormato Vancouver: de Toda IM, Vida C, Ortega E, De La Fuente M. Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice. Exp Gerontol. 2016 Nov;84:21-28.
501			_aPMID: 27582425
504			_aContiene 43 referencias
520			_aUnder stressful conditions, the expression of the chaperone Hsp70 is induced, which acts as a cellular defense mechanism. The impairment in this induction has been related to aging, whereas an increased expression has been related to longevity. Nevertheless, it is still not known if the basal levels of Hsp70 can be indicative of the aging rate of different tissues. The aim of this study was to quantify the basal levels of Hsp70 in tissues from female mice throughout their aging process including long-lived mice, as well as from prematurely aging mice (PAM). Adult, old and long-lived (6, 18 and 30months of age, respectively) female ICR-CD1 and Balb/C mice were used. Tissues with mainly mitotic (liver and renal medulla) or post-mitotic (heart, renal cortex, cerebral cortex, spleen) cells and peritoneal leukocytes from these animals as well as from adult PAM and non-prematurely aging mice (NPAM), were studied. Basal levels of Hsp70 were assessed using an ELISA method. The results showed that the aging-associated variation of the levels of Hsp70 followed a different pattern in post-mitotic and mitotic tissues, being lower or higher in old mice comparing to adults, respectively. In all the tissues analyzed the Hsp70 levels from long-lived mice were similar to those from adult animals. In addition, in adult PAM these Hsp70 levels were similar to those in chronologically old animals. In conclusion, Hsp70 basal levels show tissue-specific age-associated variations and are preserved in long-lived animals, demonstrating their role as markers of the rate of aging and longevity.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17881.pdf _ySolicitar documento
942			_2ddc _cART _n0