000			nab a22 7a 4500
999			_c17877 _d17877
003			PC17877
005			20240618115812.0
008			240618b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91509 _aMancebo Sierra, Esther _eInmunología
100			_92010 _aCastro Panete, María José _eInmunología
100			_91508 _aAllende Martínez, Luis Miguel _eInmunología
100			_91511 _aTalayero Giménez de Azcárate, Paloma _eInmunología
100			_91510 _aPaz Artal, Estela _eInmunología
245	0	0	_aHigh proportion of CD95(+) and CD38(+) in cultured CD8(+) T cells predicts acute rejection and infection, respectively, in kidney recipients. _h[artículo]
260			_bTransplant immunology, _c2016
300			_a34:33-41.
500			_aFormato Vancouver: Mancebo E, Castro MJ, Allende LM, Talayero P, Brunet M, Millán O et al. High proportion of CD95(+) and CD38(+) in cultured CD8(+) T cells predicts acute rejection and infection, respectively, in kidney recipients. Transpl Immunol. 2016 Feb;34:33-41.
501			_aPMID: 26773856
504			_aContiene 48 referencias
520			_aThe aim of this study was to find noninvasive T-cell markers able to predict rejection or infection risk after kidney transplantation. We prospectively examined T-lymphocyte subsets after cell culture stimulation (according to CD38, CD69, CD95, CD40L, and CD25 expression) in 79 first graft recipients from four centers, before and after transplantation. Patients were followed up for one year. Patients who rejected within month-1 (n=10) showed high pre-transplantation and week-1 post-transplantation percentages of CD95(+), in CD4(+) and CD8(+) T-cells (P<0.001 for all comparisons). These biomarkers conferred independent risk for early rejection (HR:5.05, P=0.061 and HR:75.31, P=0.004; respectively). The cut-off values were able to accurately discriminate between rejectors and non-rejectors and Kaplan-Meier curves showed significantly different free-of-rejection time rates (P<0.005). Patients who rejected after the month-1 (n=4) had a higher percentage of post-transplantation CD69(+) in CD8(+) T-cells than non-rejectors (P=0.002). Finally, patients with infection (n=41) previously showed higher percentage of CD38(+) in CD8(+) T-cells at all post-transplantation times evaluated, being this increase more marked in viral infections. A cut-off of 59% CD38(+) in CD8(+) T-cells at week-1, week-2 and month-2 reached 100% sensitivity for the detection of subsequent viral infections. In conclusion, predictive biomarkers of rejection and infection risk after transplantation were detected that could be useful for the personalized care of kidney recipients.
710			_9395 _aServicio de Inmunología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17877.pdf _ySolicitar documento
942			_2ddc _cART _n0