000			nab a22 7a 4500
999			_c17861 _d17861
003			PC17861
005			20240531130411.0
008			240531b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9309 _aLabiano Fontcuberta, Andrés _eNeurología
100			_92583 _aDomingo Santos, Ángela _eNeurología
100			_9892 _aBenito León, Julián _eNeurología
245	0	0	_aGray Matter Involvement in Radiologically Isolated Syndrome. _h[artículo]
260			_bMedicine, _c2016
300			_a95(13):e3208.
500			_aFormato Vancouver: Labiano Fontcuberta A, Mato Abad V, Álvarez Linera J, Hernández Tamames JA, Martínez Ginés ML, Aladro Y et al. Gray Matter Involvement in Radiologically Isolated Syndrome. Medicine (Baltimore). 2016 Mar;95(13):e3208.
501			_aPMID: 27043685 PMC4998546
504			_aContiene 54 referencias
520			_aThe unanticipated magnetic resonance imaging (MRI) detection in the brain of asymptomatic subjects of white matter lesions suggestive of multiple sclerosis has recently been named as radiologically isolated syndrome (RIS). The pathophysiological processes of RIS remain largely unknown and questions as to whether gray matter alterations actually occur in this entity are yet to be investigated in more detail. By means of a 3 T multimodal MRI approach, we searched for cortical and deep gray matter changes in a cohort of RIS patients. Seventeen RIS patients, 17 clinically isolated syndrome (CIS) patients (median disease duration from symptom onset = 12 months), and 17 healthy controls underwent MRI and neuropsychological testing. Normalized deep gray matter volumes and regional cortical thickness were assessed using FreeSurfer. SIENAX was used to obtain normalized global and cortical brain volumes. Voxelwise morphometry analysis was performed by using SPM8 software to localize regions of brain tissue showing significant changes of fractional anisotropy or mean diffusivity. Although no differences were observed between CIS and healthy controls groups, RIS patients showed significantly lower normalized cortical volume (673 ± 27.07 vs 641 ± 35.88 [cm³ × 10³, Tukey P test = 0.009) and mean thalamic volume (0.0051 ± 0.4 vs 0.0046 ± 0.4 mm, P = 0.014) compared with healthy controls. RIS patients also showed significant thinning in a number of cortical areas, that were primarily distributed in frontal and temporal lobes (P < 0.05, uncorrected). Strong correlations were observed between T2-white matter lesion volume and regional cortical thickness (rho spearman ranging from 0.60 to 0.80). Our data suggest that white matter lesions on T2-weighted images are not the only hallmark of RIS. Future longitudinal studies with larger samples are warranted to better clarify the effect of RIS-related white matter lesions on gray matter tissue.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17861.pdf _ySolicitar documento
942			_2ddc _cART _n0