000			nab a22 7a 4500
999			_c17706 _d17706
003			PC17706
005			20231023121523.0
008			231023b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93108 _aLópez Padilla, Daniel Eduardo _eNeumología
100			_993 _aAlonso Moralejo, Rodrigo _eNeumología
100			_9253 _aTorre Carazo, Salvador de la _eNeumología
100			_91172 _aDíaz de Atauri Rodríguez de los Ríos, María Josefa _eNeumología
245	0	0	_aContinuous positive airway pressure and survival of very elderly persons with moderate to severe obstructive sleep apnea. _h[artículo]
260			_bSleep medicine, _c2016
300			_a19:23-9.
500			_aFormato Vancouver: López Padilla D, Alonso Moralejo R, Martínez García MÁ, De la Torre Carazo S, Díaz de Atauri MJ. Continuous positive airway pressure and survival of very elderly persons with moderate to severe obstructive sleep apnea. Sleep Med. 2016 Mar;19:23-9.
501			_aPMID: 27198943
504			_aContiene 31 referencias
520			_aObjective: There is evidence of a beneficial effect of long-term continuous positive airway pressure (CPAP) on survival in elderly persons with obstructive sleep apnea (OSA), although the usual age cut off is between 60 and 70 years of age. Our objective was to determine this effect in very elderly patients (ie, those ≥80 years of age). Methods: An observational study of a historic cohort of very elderly persons with moderate to severe OSA (apnea-hypopnea index ≥20) and the effect of long-term CPAP on their survival was performed. Two groups were formed: one prescribed CPAP treatment (≥4 hours per night), and one without CPAP treatment. Survival analyses, including Kaplan-Meier curves and Cox models, were carried out to determine the association of long-term CPAP with longer survival, Results: A total of 155 very elderly persons (84 men and 71 women, mean age 81.5 ± 1.5 years) were followed up for 53 months (interquartile range, 41-77 months); 83 deaths occurred. CPAP was prescribed to 132 patients, and adherence was observed in 79 (60%). Kaplan-Meier curves showed longer survival in the treated OSA group (91 months, 95% confidence interval [CI] = 76-106) than in the untreated OSA group (52 months, 95% CI 41-64), which was statistically significant (log-rank 16.9, p < 0.0001). Although history of stroke was significantly associated with higher mortality (hazard ratio [HR] = 2.18, 95% CI = 1.14-4.17, p = 0.02), CPAP treatment was associated with higher survival rates (HR = 0.46, 95% CI = 0.27-0.78, p = 0.004) in an adjusted Cox analysis. Conclusions: CPAP treatment might be associated with a longer survival in very elderly persons with moderate to severe OSA.
710			_988 _aServicio de Neumología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17706.pdf _ySolicitar documento
942			_2ddc _cART _n0