000			nab a22 7a 4500
999			_c17139 _d17139
003			PC17139
005			20230123131456.0
008			230123b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93126 _aGuisasola, Eduardo _eInstituto de Investigación imas12
100			_92995 _aBaeza, Alejandro _eInstituto de Investigación imas12
100			_93127 _aTalelli, Marina _eInstituto de Investigación imas12
100			_92843 _aArcos, Daniel _eInstituto de Investigación imas12
100			_92644 _aVallet Regí, María _eInstituto de Investigación imas12
245	0	0	_aMagnetic-Responsive Release Controlled by Hot Spot Effect. _h[artículo]
260			_bLangmuir : the ACS journal of surfaces and colloids, _c2015
300			_a31(46):12777-82.
500			_aFormato Vancouver: Guisasola E, Baeza A, Talelli M, Arcos D, Moros M, de la Fuente JM et al. Magnetic-Responsive Release Controlled by Hot Spot Effect. Langmuir. 2015 Nov 24;31(46):12777-82.
501			_aPMID: 26536300
504			_aContiene 31 referencias
520			_aMagnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of magnetic cores to generate thermal energy in the presence of an alternating magnetic field. Then, the temperature increase triggers the drug release. Despite this potential, the rapid heat dissipation in living tissues is a serious hindrance for their clinical application. It is hypothesized that magnetic cores could act as hot spots, this is, produce enough heat to trigger the release without the necessity to increase the global temperature. Herein, a nanocarrier has been designed to respond when the temperature reaches 43 °C. This material has been able to release its payload under an alternating magnetic field without the need of increasing the global temperature of the environment, proving the efficacy of the hot spot mechanism in magnetic-responsive drug delivery devices.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17139.pdf _ySolicitar documento
942			_2ddc _cART _n0